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Toplam kayıt 13, listelenen: 1-10
Microbiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living RodentSpalax leucodon
(Mary Ann Liebert, Inc, 2020)
With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the ...
Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative Medicine
(Mary Ann Liebert, Inc, 2020)
Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ...
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
(Academic Press Inc Elsevier Science, 2020)
The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ...
The first report on circulating microRNAs at Pre- and Post-metamorphic stages of axolotls
(Elsevier B.V., 2020)
MicroRNAs (miRNAs) are endogenously coded small RNAs, implicated in post-transcriptional gene regulation by targeting messenger RNAs (mRNAs). Circulating miRNAs are cell-free molecules, found in body fluids, such as blood ...
Cellular and Molecular Comparison of Glioblastoma Multiform Cell Lines
(CUREUS INC, 2021)
Glioblastoma multiform (GBM) is one of the most severe tumor types. It is highly invasive and characterized as a grade IV neoplastic cancer. Its resistance to chemotherapy-temozolomide (TMZ treatment)-in combination with ...
Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues
(Nature Research, 2019)
Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ...
Axolotl: A resourceful vertebrate model for regeneration and beyond
(WILEY, 2022)
The regenerative capacity varies significantly among the animal kingdom. Successful regeneration program in some animals results in the functional restoration of tissues and lost structures. Among the highly regenerative ...
A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
(Springer Science and Business Media B.V., 2023)
Background: Despite recent advances in drug discovery, cancer is still one of the most lethal health problems worldwide. In most cases, standard therapy methods and multi-modal treatments fail, and new therapeutic approaches ...
A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway
(Elsevier B.V., 2023)
Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to identify new therapeutic approaches ...
Association between the anthropometric measurements and dietary habits on telomere shortening in healthy older adults: A-cross-sectional study
(John Wiley and Sons Inc, 2023)
im: This study aimed to evaluate the effect of anthropometric measurements and dietary habits on telomere length in healthy older residents in rural and urban areas. Methods: This was a cross-sectional study. The study ...