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Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative Medicine
(Mary Ann Liebert, Inc, 2020)
Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ...
In Silico Analysis of a Highly Mutated Gene in Cancer Provides Insight into Abnormal mRNA Splicing: Splicing Factor 3B Subunit 1(K700E) Mutant
(Mdpi, 2020)
Cancer is the second leading cause of death worldwide. The etiology of the disease has remained elusive, but mutations causing aberrant RNA splicing have been considered one of the significant factors in various cancer ...
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
(Academic Press Inc Elsevier Science, 2020)
The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ...
UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searches
(Oxford Univ Press, 2015)
Motivation: UniRef databases provide full-scale clustering of UniProtKB sequences and are utilized for a broad range of applications, particularly similarity-based functional annotation. Non-redundancy and intra-cluster ...
ML-AdVInfect: A Machine-Learning Based Adenoviral Infection Predictor
(Frontiers, 2021)
Adenoviruses (AdVs) constitute a diverse family with many pathogenic types that infect a broad range of hosts. Understanding the pathogenesis of adenoviral infections is not only clinically relevant but also important to ...
In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases
(Bmc, 2014)
Background: Near universal administration of vaccines mandates intense pharmacovigilance for vaccine safety and a stringently low tolerance for adverse events. Reports of autoimmune diseases (AID) following vaccination ...
First case with RANBP2 biallelic mutation and severe acute necrotizing encephalopathy phenotype
(Elsevier B.V., 2022)
Familial acute necrotizing encephalopathy (ANE) is a rapidly progressive encephalopathy that can occur after common viral infections at different stages of life. The clinical findings of 2 siblings diagnosed with ANE were ...
A correlation coefficient-based feature selection approach for virus-host protein-protein interaction prediction
(Plos, 2023)
Prediction of virus-host protein-protein interactions (PPI) is a broad research area where various machine-learning-based classifiers are developed. Transforming biological data into machine-usable features is a preliminary ...
Machine Learning Methods for Virus–Host Protein–Protein Interaction Prediction
(Humana Press Inc., 2023)
The attachment of a virion to a respective cellular receptor on the host organism occurring through the virus–host protein–protein interactions (PPIs) is a decisive step for viral pathogenicity and infectivity. Therefore, ...
DEVOUR: Deleterious Variants on Uncovered Regions in Whole-Exome Sequencing
(PMC, 2023)
The discovery of low-coverage (i.e. uncovered) regions containing clinically significant variants, especially when they are related to the patient's clinical phenotype, is critical for whole-exome sequencing (WES) based ...