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Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements
(Mdpi, 2019)
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration ...
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets
(Elsevier, 2021)
Oncogenic transformation has been the major cause of global mortality since decades. Despite established therapeutic regimes, majority of cancer patients either present with tumor relapse, refractory disease or therapeutic ...
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
(Elsevier, 2021)
Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural ...
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target
(Elsevier, 2021)
Notch signaling, an evolutionarily conserved signaling cascade, is critical for normal biological processes of cell differentiation, development, and homeostasis. Deregulation of the Notch signaling pathway has been ...