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dc.contributor.authorAltuntaş, Derya Bal
dc.contributor.authorNalkıran, Hatice S.
dc.contributor.authorAslan, Sema
dc.contributor.authorYolcu, Zuhal
dc.date.accessioned2022-05-30T11:53:32Z
dc.date.available2022-05-30T11:53:32Z
dc.date.issued2022en_US
dc.identifier.citationBal Altuntaş, D., Nalkıran, H.S., Aslan, S. et al. Development of MoS2 and Au nanoparticle ıncluding disposable CEA-based immuno-cytosensor platforms. Chem. Pap. (2022). https://doi.org/10.1007/s11696-022-02240-xen_US
dc.identifier.issn0366-6352 / 2585-7290
dc.identifier.urihttps://doi.org/10.1007/s11696-022-02240-x
dc.identifier.urihttps://hdl.handle.net/20.500.12809/10002
dc.description.abstractIn this study, an electrochemical biosensor for determination of Carcinoembryonic antigen (CEA) biomarker using human breast ductal adenocarcinoma (MCF-7) and human ovarian adenocarcinoma (SK-OV-3) cancer cells was presented. Disposable pencil graphite electrodes (PGE) has been modified with Au nanoparticle (Au NP) and MoS2 nanostructure dispersed chitosan (Cs) matrix. Therefore, the electrochemical interaction between the antibody-electrode surface was facilitated. Under optimal conditions, the immunosensor exhibited high sensitivity toward CEA biomarker in the low concentration range 0.01-10 ng mL(-1), with the detection limit of 1.93 ng mL(-1) and relative standard deviation of 4.65 (n = 5). The results indicated that even very small changes in CEA concentration can be sensed with the presented system. Also, recovery of the immunosensor found as 98 +/- 3% in the real sera samples containing dopamine and ascorbic acid. It has a great potential in the clinical screening of divergent cancer biomarkers. Experiments were conducted to determine the number of normal cell hGF and cancer cells adhered and attached on immuno-cytosensor surfaces. CEA-positive MCF-7 cells have shown great potential for adhesion and attachment to MoS2/Cs/Au/Anti-CEA/CEA surface better than CEA-negative cells. The developed immuno-cytosensor exhibited very promising results for the future biosensor studies.en_US
dc.item-language.isoengen_US
dc.publisherSPRINGER INTERNATIONAL PUBLISHING AGen_US
dc.relation.isversionof10.1007/s11696-022-02240-xen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarcinoembriyonic antigenen_US
dc.subjectNanoparticleen_US
dc.subjectHuman breast ductal adenocarcinomaen_US
dc.subjectHuman ovarian adenocarcinomaen_US
dc.subjectImmunosensor-cytosensoren_US
dc.titleDevelopment of MoS2 and Au nanoparticle including disposable CEA-based immuno-cytosensor platformsen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Kimya Bölümüen_US
dc.contributor.institutionauthorAslan, Sema
dc.relation.journalCHEMICAL PAPERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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