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dc.contributor.authorSarac, Nurdan
dc.contributor.authorUgur, Aysel
dc.contributor.authorKaraca, Inci Rana
dc.date.accessioned2020-11-20T14:42:02Z
dc.date.available2020-11-20T14:42:02Z
dc.date.issued2019
dc.identifier.issn2630-6158
dc.identifier.issn2651-2823
dc.identifier.urihttps://doi.org/10.26650/eor.20197852
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TXpNd01UWTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12809/1015
dc.descriptionSarac, Nurdan/0000-0001-7676-542X; KARACA, Inci Rana/0000-0003-1870-2687en_US
dc.descriptionWOS: 000488851500001en_US
dc.descriptionPubMed ID: 31309193en_US
dc.description.abstractPurpose Hemostatic agents are used to control hemorrhage and the gingival crevicular fluid for dental applications. In this study; the antimutagenic and antioxidant activities of aluminum chloride (AlCl3), a topical hemostatic agent used especially in the fields of dermatology and dentistry, were determined. To our knowledge, this is the first study that investigates these properties. Materials and Methods The antioxidant activity was determined by DPPH free radical scavenging and beta-carotene-linoleic acid bleaching assays. The antimutagenic activity was evaluated with the Ames Salmonella/microsome mutagenicity test using Salmonella typhimurium TA98 and TA100 strains. Results The total antioxidant activity of AlCl3, determined by beta-carotene bleaching assay was found to be 25.59 +/- 2.55% and the DPPH scavenging activity of AlCl3 was determined as 17.49 +/- 3.07%. AlCl3 showed not any mutagenicity at the tested concentrations by the AMES test used S. typhimurium TA98 and TA100. This drug demonstrated antimutagenic effects at the test concentrations and the strongest antimutagenic activity was observed on 1.25 mg.mL(-1)/plate concentration of AlCl3. Conclusion AlCl3 showed potent antimutagenic and antioxidant activities and these properties are significant for dentistry and dermatology.en_US
dc.item-language.isoengen_US
dc.publisherIstanbul Univ Press, Istanbul Univ Rectorateen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlcl3en_US
dc.subjectAmesen_US
dc.subjectOxidative Stressen_US
dc.subjectDPPHen_US
dc.subjectHemostaticen_US
dc.titleEvaluation of antioxidant and antimutagenic activities of aluminum chlorideen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Sarac, Nurdan] Mugla Sitki Kocman Univ, Fac Sci, Dept Biol, Mugla, Turkey -- [Ugur, Aysel] Gazi Univ, Fac Dent, Dept Basic Sci, Sect Med Microbiol, Ankara, Turkey -- [Karaca, Inci Rana] Gazi Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Ankara, Turkeyen_US
dc.identifier.doi10.26650/eor.20197852
dc.identifier.volume53en_US
dc.identifier.issue2en_US
dc.identifier.startpage51en_US
dc.identifier.endpage55en_US
dc.relation.journalEuropean Oral Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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