Basit öğe kaydını göster

dc.contributor.authorKılınçarslan Aksoy, Özge
dc.contributor.authorSeçme, Mücahit
dc.contributor.authorMammadov, Ramazan
dc.date.accessioned2023-01-31T14:14:20Z
dc.date.available2023-01-31T14:14:20Z
dc.date.issued2022en_US
dc.identifier.citationAksoy, Ö. K., Seçme, M., & Mammadov, R. (2022). Antioxidant, Cytotoxicity, Apoptotic Properties of Extracts of Andricus sternlichti galls and Their Phenolic Characterisation by HPLC. Chemistry & Biodiversity.en_US
dc.identifier.isbn16121872
dc.identifier.otherPubMed ID 36478153
dc.identifier.urihttps://doi.org/10.1002/cbdv.202200742
dc.identifier.urihttps://hdl.handle.net/20.500.12809/10509
dc.description.abstractQuercus L. galls have been used in Western and Eastern cultures for various diseases in traditional medicine. Galls are also used in the East for many purposes, including consumption as food, commercial inks, leather tanning. In the current study, Andricus sternlichti Bellido, Pujade-Villar & Melika, 2003 galls were extracted in different solvents. The possible antioxidant effects of gall extracts were determined using 7 different methods (β-carotene-linoleic acid assay, Phosphomolybdenum assay, DPPH and ABTS radical scavenging activity, CUPRAC and FRAP assay, Metal Chelating activity) to support each other. Total phenolic, flavonoid and tannin amounts of extracts are calculated by using standard curves. In addition, HPLC method used to characterize the phenolic component with 15 different standards. The MIA PaCa-2 cell lines was preferred to identify possible cytotoxic activities of galls. Expression of some genes (Bax, Bcl-2, FAS, BID, caspase-3, caspase-8, caspase-9, caspase-10, FADD, TRADD) role in the apoptosis was determined to investigate apoptotic effects of extracts. According the results, the gall extracts of A. sternlichti may be considered as a potential source of biological agents for their antioxidant capacity and rich bioactive compounds. The gall extracts exhibit antiproliferative activity via regulating expressions of apoptotic genesen_US
dc.item-language.isoengen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.isversionof10.1002/cbdv.202200742en_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectHPLCen_US
dc.subjectXTTen_US
dc.subjectPCRen_US
dc.subjectAnticancer activity.en_US
dc.titleAntioxidant, Cytotoxicity, Apoptotic Properties of Extracts of Andricus sternlichti galls and Their Phenolic Characterisation by HPLCen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.authorID0000-0003-2218-5336en_US
dc.contributor.institutionauthorMammadov, Ramazan
dc.relation.journalChemistry and Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster