Kurum Yazarı "Elbe, Hülya" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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8 Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats
Elbe, Hülya; Esrefoglu, M.; Vardi, N.; Taslidere, E.; Ozerol, E.; Tanbek, K. (Sage Publications Ltd, 2015)In this study, effects of melatonin, quercetin and resveratrol on hepatocellular injury in streptozotocin (STZ)-induced experimental diabetes were aimed to be investigated by histological and biochemical methods. Thirty-five ... -
Aminoguanidine mitigates apoptosis, testicular seminiferous tubules damage, and oxidative stress in streptozotocin-induced diabetic rats
Orman, Doğan; Vardı, Nigar; Ateş, Burhan; Taşlıdere, Elif; Elbe, Hülya (Churchill Livingstone, 2015)This study aimed to investigate the effect of aminoguanidine (AG) against testicular damage streptozotocin (STZ) induced diabetes. Thirty two rats were separated into four groups: control, AG, STZ and STZ + AG. In the STZ ... -
Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats
Abdulkareem Aljumaily, Sara Asaad; Demir, Mehmet; Elbe, Hülya; Yiğittürk, Gürkan; Biçer, Yasemin; Altınöz, Eyüp (Springer, 2021)Doxorubicin (DOX) is a well-known chemotherapeutic drug for most malignancies including breast cancer and leukemia whilst the usage of DOX is limited owing to its cardiotoxicity. In the present study, we aimed to investigate ... -
Beneficial effects of quercetin on renal injury and oxidative stress caused by ciprofloxacin in rats: A histological and biochemical study
Elbe, Hülya; Doğan, Z.; Taşlıdere, E.; Çetin, A.; Türköz, Y. (Sage Publications Ltd, 2016)Ciprofloxacin is a broad-spectrum quinolone antibiotic commonly used in clinical practice. Quercetin is an antioxidant belongs to flavonoid group. It inhibits the production of superoxide anion. In this study, we aimed to ... -
Cardioprotective potential of melatonin, quercetin and resveratrol in an experimental model of diabetes
Bostancıeri, N.; Elbe, Hülya; Vardı, N. (Taylor and Francis Ltd., 2021)Oxygen radicals participate in the pathogenesis of heart damage. Diabetes accelerates the formation of reactive oxygen species (ROS). We investigated the effects of the antioxidants, melatonin, quercetin and resveratrol, ... -
Comparison of ultrastructural changes and the anticarcinogenic effects of thymol and carvacrol on ovarian cancer cells: which is more effective?
Elbe, Hülya; Yiğittürk, Gürkan; Cavusoglu, Turker; Baygar, Tuba; Özgül Önal, Melike; Öztürk, Feral (Taylor & Francis Inc, 2020)Ovarian cancer is the seventh most common cancer worldwide in women. Many anticancer drugs are currently used clinically have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) ... -
Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats
Karayakalı, Melike; Altınöz, Eyüp; Elbe, Hülya; Koca, Oğuzhan; Önal, Melike Özgül; Biçer, Yasemin; Demir, Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Diabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence that leads to significant morbidity and mortality. The liver plays a vital role in glycemic regulation in physiological and ... -
Dexpanthenol reduces diabetic nephropathy and renal oxidative stress in rats
Tutun, B.; Elbe, Hülya; Vardı, N.; Parlakpınar, H.; Polat, A.; Günaltılı, M.; Yaşar, E. N. (Taylor & Francis Ltd, 2019)Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress contributes to the development of diabetic complications. Dexpanthenol (Dxp) is the biological active form of pantothenic acid. We ... -
Effect of a honey and arginine-glutamine-hydroxymethylbutyrate mixture on the healing of colon anastomosis in rats immunosuppressed with tacrolimus
Akbulut, S.; Dogan, Z.; Baskiran, A.; Elbe, Hülya; Turkoz, Y. (Taylor & Francis Ltd, 2019)We compared the effect of honey and a mixture of arginine-glutamine-hydroxymethylbutyrate (AGHMB) on healing of a descending colon anastomosis in rats that were immunosuppressed with tacrolimus (Tac). Sprague-Dawley rats ... -
Effects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarction
Demir, Mehmet; Altınöz, Eyüp; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Karayakalı, Melike (Taylor and Francis Ltd., 2021)The present study aimed to analyze the effects of pinealectomy and crocin treatment in isoproterenol-induced myocardial damage. Seventy rats were divided into seven groups: control, sham control, pinealectomy (PNX), ... -
Effects of varenicline on lung tissue in the animal model
Ermis, Hilal; Parlakpinar, Hakan; Elbe, Hülya; Vardi, Nigar; Polat, Alaaddin; Gulbas, Gazi (Soc Brasileira Pneumologia Tisiologia, 2020)Objective: This study aimed to investigate acute and chronic effects of varenicline on lung tissue in an experimental study. Methods: A total of 34 rats were randomly allocated into study (varenicline) and control groups. ... -
Endotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonates
Özgöçer, Tuba; Yıldız, Sedat; Elbe, Hülya; Vardı, Nigar (Canadian Science Publishing, Nrc Research Press, 2015)Bacterial toxins are widespread in the environment as well as in the digestive system of humans and animals. Toxin from Gram-negative bacteria (endotoxin or lipopolysaccharide; LPS) has a life-long programming effect on ... -
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis
Haqi Ballur, Arwa Fadil; Altınöz, Eyüp; Yiğittürk, Gürkan; Özgül Önal, Melike; Elbe, Hülya (Springer, 2022)Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous ... -
Leptin Accelerates Endothelial Wound Healing: Role of Endothelial Nitric Oxide Synthase Expression
Yiğittürk, Gürkan; Önal, Melike Özgül; Subaşı, Ekin; Doğan, Beyza; Türkmenoğlu, Melih; Kaplan, Merve; Yaşar, Volkan; Elbe, Hülya; Öztürk, Feral; 0000-0002-5315-253X (Turkish Society of Cardiology, 2022)Background: The endothelium is crucial for the control of vascular homeostasis and plays a role in angiogenesis. Leptin, a protein released mainly by adipose tissue, plays a key role in the regulation of energy balance and ... -
Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress
Altınöz, Eyüp; Öner, Zulal; Elbe, Hülya; Üremiş, Nuray; Üremiş, Muhammed (Taylor and Francis Ltd., 2021)The aim of the present study was to investigate the therapeutic and protective effects of linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were divided into 8 groups as follows; Control, ... -
Protective effects of quercetin against testis damage caused by cisplatin
Bostancıeri, Nuray; Taşlıdere, Aslı; Elbe, Hülya; Taşlıdere, Elif (Taylor and Francis Ltd., 2021)We investigated the effects of quercetin on cisplatin induced testicular toxicity using histopathological, immunohistochemical and biochemical methods. We used four groups of Wistar albino male: control, quercetin, cisplatin, ... -
Quercetin protection against ciprofloxacin induced liver damage in rats
Taşlıdere, E.; Doğan, Z.; Elbe, Hülya; Vardı, N.; Çetin, A.; Türköz, Y. (Taylor & Francis Ltd, 2016)Ciprofloxacin is a common, broad spectrum antibacterial agent; however, evidence is accumulating that ciprofloxacin may cause liver damage. Quercetin is a free radical scavenger and antioxidant. We investigated histological ... -
Resveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: Role of iNOS expression
Elbe, Hülya; Gül, Mehmet; Çetin, Aslı; Taşlıdere, Elif; Özyalın, Fatma; Türköz, Yusuf; Otlu, Ali (Taylor & Francis Inc, 2018)Introduction: Hepatotoxicity is amajor complication of acetaminophen (APAP), a widely used analgesic and antipyretic drug. Resveratrol (RSV) is a naturally occurring diphenol and it has anticancer, antioxidant, and ... -
Synovial fluid niche promoted differentiation of dental follicle mesenchymal stem cells toward chondrogenesis in rheumatoid arthritis
Genç, Deniz; Sezer Kürkçü, Merve; Yiğittürk, Gürkan; Günaydın, Burcu; Elbe, Hülya; Aladağ, Akın; Çöl, Bekir; Tarhan, Emine Figen (TURKISH LEAGUE AGAINST RHEUMATISM, 2022)Objectives: In this study, we aimed to investigate the differentiation potential of dental follicle mesenchymal stem cells (MSCs) in the synovial fluid (SF) niche of early-onset or end-stage rheumatoid arthritis (RA). ... -
Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats
Keelo, Rihab Mudhafar Ali Hammood; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Koca, Oğuzhan; Karayakalı, Melike; Acar, Derya; Altınöz, Eyüp (Elsevier, 2022)One of the most common complications of diabetes is diabetic nephropathy (DN). Uncontrolled hyperglycemia leads to histopathologic alterations in the kidney that prevent normal renal function. This study aimed to explore ...