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dc.contributor.authorSener, Elif Funda
dc.contributor.authorSahin, Mustafa Caglar
dc.contributor.authorTaheri, Serpil
dc.contributor.authorBayramov, Keziban Korkmaz
dc.contributor.authorMarasli, Mert Kahraman
dc.contributor.authorZararsiz, Gokmen
dc.contributor.authorOztop, Didem Behice
dc.date.accessioned2020-11-20T14:54:51Z
dc.date.available2020-11-20T14:54:51Z
dc.date.issued2017
dc.identifier.issn2475-0573
dc.identifier.issn2475-0581
dc.identifier.urihttps://doi.org/10.1080/24750573.2017.1293248
dc.identifier.urihttps://hdl.handle.net/20.500.12809/2182
dc.descriptionBAYRAM, KEZIBAN KORKMAZ/0000-0002-1228-1298; Zararsiz, Gokmen/0000-0001-5801-1835en_US
dc.descriptionWOS: 000401318800005en_US
dc.description.abstractObjective: Autism spectrum disorders (ASDs) is a heterogeneous neuropsychiatric disorder with widespread abnormalities of social interaction and communication, showing severely restricted interests and extreme repetitive behavior. The relationship between aggressive behavior, insensitivity to pain, and ASDs could not be explained completely. Therefore, we aimed to contribute to the etiology by examining the gene expressions of OPRL1, TACR1, and HTR1E in patients with ASDs. Methods: This study was held in the Genome and Stem Cell Research Center of Erciyes University. In this present study, the expressions of OPRL1, TACR1, and HTR1E genes were studied in 22 ASD patients and 14 healthy controls. Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) was used for gene expression studies. Results: There was a statistically significant difference in terms of the expression of the three genes, which we examined between the ASD patient and control groups. Positive and strong correlations were obtained between the three gene expressions in the ASD group and this finding was found to be statistically significant. Conclusions: Considering all these findings, large-scale and new researches are needed for revealing the roles of genes and their pathways which are related to aggression and insensitivity to pain in ASDs. Our results will lead to new research studies in this field.en_US
dc.item-language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutism Spectrum Disordersen_US
dc.subjectAggressionen_US
dc.subjectInsensitivity To Painen_US
dc.subjectExpressionen_US
dc.titleA preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disordersen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Sener, Elif Funda; Taheri, Serpil] Erciyes Univ, Sch Med, Dept Med Biol, Kayseri, Turkey -- [Sahin, Mustafa Caglar; Marasli, Mert Kahraman] Erciyes Univ, Sch Med, Kayseri, Turkey -- [Bayramov, Keziban Korkmaz] Erciyes Univ, Sch Med, Dept Med Genet, Kayseri, Turkey -- [Zararsiz, Gokmen] Erciyes Univ, Sch Med, Dept Biostat, Kayseri, Turkey -- [Canpolat, Mehmet] Erciyes Univ, Sch Med, Dept Child Neurol, Kayseri, Turkey -- [Sahin, Nilfer] Mugla Univ, Sch Med, Dept Child Pscyhiat, Mugla, Turkeyen_US
dc.identifier.doi10.1080/24750573.2017.1293248
dc.identifier.volume27en_US
dc.identifier.issue1en_US
dc.identifier.startpage24en_US
dc.identifier.endpage29en_US
dc.relation.journalPsychiatry and Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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