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dc.contributor.authorOzcan, Onder
dc.contributor.authorKara, Murat
dc.contributor.authorYumrutas, Onder
dc.contributor.authorBozgeyik, Esra
dc.contributor.authorBozgeyik, Ibrahim
dc.contributor.authorCelik, Ozgur Ilhan
dc.date.accessioned2020-11-20T15:02:31Z
dc.date.available2020-11-20T15:02:31Z
dc.date.issued2016
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.urihttps://doi.org/10.1007/s13277-015-4550-4
dc.identifier.urihttps://hdl.handle.net/20.500.12809/2525
dc.descriptionOzcan, Onder/0000-0001-8252-3339; bozgeyik, ibrahim/0000-0003-1483-2580;en_US
dc.descriptionWOS: 000376465800108en_US
dc.descriptionPubMed ID: 26643896en_US
dc.description.abstractDeregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC). Thus, determining miRNA targets of genes that play critical role in the malignant transformation is very important. Here, expression levels of tumor suppressor microtubule-associated tumor suppressor 1 (MTUS1) and its regulatory miRNAs were reported. Predicted and validated targets of MTUS1 gene was determined by a computational approach. Expressions of MTUS1 and miRNAs were determined by using 96.96 Dynamic Array T integrated fluidic circuit (Fluidigm). As a result, MTUS1 levels were found to be diminished in formalinfixed, paraffin-embedded (FFPE) tissue samples of CRC patients compared to controls. Also, several of MTUS1 targeting miRNAs were found to be upregulated in CRC samples (miR-373-3p, 183-5p, 142-5p, 200c-3p, 19a-3p, -20a-5p, -181a-5p, -184, -181d-5p, -372-3p, 27b-3p, 98-5p, -let-7i-5p, -let-7d-5p, -let-7g-5p, -let-7b-5p, and -let-7c-5p). Of these miRNAs, miR-135b-5p, -373-3p, 183-5p, 142-5p, 200c-3p, 19a-3p showed marked expression levels. In contrast, expression levels of let-7a-5p, 7e-5p, 7f-5p, hsa-miR-125a-5p, and 125b-5p were found to be downregulated in CRC tissues. Accordingly, some of the overexpressed miRNAs especially the miR-135b-5p, -373-3p, 183-5p, 142-5p, 200c-3p, and 19a-3p may play key roles in CRC pathophysiology through MTUS1. In contrast, let-7a-5p, 7e-5p, 7f-5p, miR-125a-5p, and 125b-5p may play important roles in CRC carcinogenesis independent from the MTUS1. In conclusion, MTUS1 targeting miRNAs may play key roles in the development of CRC by downregulating tumor suppressor MTUS1.en_US
dc.description.sponsorshipScientific Research Projects Management Unit of Mugla Sitki Kocman UniversityMugla Sitki Kocman University [13/152]en_US
dc.description.sponsorshipThis study was funded by a project from the Scientific Research Projects Management Unit of Mugla Sitki Kocman University (grant number 13/152).en_US
dc.item-language.isoengen_US
dc.publisherSage Publications Ltden_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectMTUS1en_US
dc.subjectMirnaen_US
dc.subjectMir-135b-5pen_US
dc.subjectMir-373-3pen_US
dc.subjectMir-183-5pen_US
dc.titleMTUS1 and its targeting miRNAs in colorectal carcinoma: significant associationsen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Ozcan, Onder] Mugla Sitki Kocman Univ, Fac Med, Dept Gen Surg, Mugla, Turkey -- [Kara, Murat] Mugla Sitki Kocman Univ, Fac Med, Dept Med Genet, Mugla, Turkey -- [Yumrutas, Onder; Bozgeyik, Ibrahim] Adiyaman Univ, Fac Med, Dept Med Biol, Adiyaman, Turkey -- [Bozgeyik, Esra] Gaziantep Univ, Fac Med, Dept Med Biol & Genet, Gaziantep, Turkey -- [Celik, Ozgur Ilhan] Mugla Sitki Kocman Univ, Fac Med, Dept Pathol, Mugla, Turkeyen_US
dc.identifier.doi10.1007/s13277-015-4550-4
dc.identifier.volume37en_US
dc.identifier.issue5en_US
dc.identifier.startpage6637en_US
dc.identifier.endpage6645en_US
dc.relation.journalTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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