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dc.contributor.authorElmas, Oğuz
dc.contributor.authorElmas, Onur
dc.contributor.authorAlıcıgüzel, Yakup
dc.contributor.authorŞimsek, Tayyup
dc.date.accessioned2020-11-20T15:03:37Z
dc.date.available2020-11-20T15:03:37Z
dc.date.issued2016
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.urihttps://doi.org/10.3109/01443615.2015.1030608
dc.identifier.urihttps://hdl.handle.net/20.500.12809/2755
dc.description0000-0002-8380-0999en_US
dc.descriptionWOS: 000374886800009en_US
dc.descriptionPubMed ID: 26366935en_US
dc.description.abstractIt is controversial that uric acid (UA) levels are related to the severity of hypertension in preeclampsia (PE). Our aim in this study was to determine whether UA, xanthine oxidase activity (XOA), allantoin and nitrite levels are related to arterial blood pressure (BP) in PE. We formed a control group (n = 20) and a PE group (n = 20) for the study. Their BPs and plasma UA, XOA, allantoin and nitrite levels were measured. The values from the control and PE pregnant women were assessed via a Wilcoxon matched-pairs test. A Pearson correlation test was also performed. In addition, the diagnostic value of these tests was evaluated via receiver operating characteristic (ROC) analysis. The BP, UA, XOA and allantoin levels in the PE patients were found to be higher when compared with those of the pregnant controls. The UA, XOA and allantoin levels showed high correlations with BP in cases of PE. However, there was no superiority among the correlations. No differences were observed between the groups in terms of nitrite levels and the relationship between nitrite and BP. UA, XOA and allantoin levels may be high due to placental cell death because of abnormal trophoblastic activity observed in PE. Moreover, the reactive oxygen products that are created during the genetic material degradation may explain how UA, XOA and allantoin levels are related to BP. According to ROC analysis, UA, XOA and allantoin assays are reliable predictors for the determination of PE.en_US
dc.description.sponsorshipAkdeniz University Research FundAkdeniz University [2004.04.0103.001]en_US
dc.description.sponsorshipThis study was supported by the Akdeniz University Research Fund (grant number: 2004.04.0103.001).en_US
dc.item-language.isoengen_US
dc.publisherTaylor & Francis Incen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllantoinen_US
dc.subjectNitriteen_US
dc.subjectPreeclampsiaen_US
dc.subjectUric Aciden_US
dc.subjectXanthine Oxidase Activityen_US
dc.titleThe relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsiaen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorElmas, Onur
dc.identifier.doi10.3109/01443615.2015.1030608
dc.identifier.volume36en_US
dc.identifier.issue1en_US
dc.identifier.startpage34en_US
dc.identifier.endpage38en_US
dc.relation.journalJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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