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dc.contributor.authorAlataş, Ömer Doğan
dc.contributor.authorGurger, Mehtap
dc.contributor.authorAteşçelik, Metin
dc.contributor.authorYıldız, Mustafa
dc.contributor.authorDemir, Caner Feyzi
dc.contributor.authorEkingen, Evren
dc.contributor.authorAcar, Ethem
dc.date.accessioned2020-11-20T15:04:23Z
dc.date.available2020-11-20T15:04:23Z
dc.date.issued2015
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000002007
dc.identifier.urihttps://hdl.handle.net/20.500.12809/2874
dc.descriptionWOS: 000369537400051en_US
dc.descriptionPubMed ID: 26559295en_US
dc.description.abstractThe authors evaluated neuron-specific enolase (NSE), S100 calcium-binding protein B (S100B), and heat shock protein 70 (HSP 70) levels and their relationships with in-hospital mortality, Glasgow Coma Scale (GCS) scores, and National Institute of Health Stroke Scale (NIHSS) scores.In total, 35 patients older than 18 years were presented to our emergency department and were diagnosed with non-traumatic intracranial hemorrhage (ICH) and 32 healthy controls were included. Blood samples were drawn on days 0 and 5.S100 calcium-binding protein B and HSP levels were significantly higher in patients than in controls on days 0 and 5. Neuron-specific enolase levels were higher in patients than in controls on day 0, but there was no significant difference on day 5.S100 calcium-binding protein B was negatively correlated with GCS, whereas it was positively correlated with NIHSS and bleeding volume. There was also a negative correlation between NSE and GCS, but it was not statistically significant. In addition, no significant correlation was found in terms of bleeding volume or NIHSS. Heat shock protein 70 was negatively correlated with GCS and positively correlated with bleeding volume and NIHSS, but these results were not statistically significant. S100 calcium-binding protein B and HSP 70 levels were significantly higher in those who died compared with survivors. The areas under the curve of S100 B, NSE, and HSP 70 for mortality were 0.635, 0.477, and 0.770, respectively.Neuron-specific enolase, S100B, and HSP 70 levels are simple, inexpensive, and objective measures in cases of ICH. These tests can be used to support an assessment for screening ICH patients with clinical scoring systems, such as GCS and NIHSS.en_US
dc.description.sponsorshipFirat UniversityFirat University [TF.11.75]en_US
dc.description.sponsorshipThis study was published as a poster at the 9th National Congress of Emergency Medicine in Turkey (23-26 May 2013, Antalya, Turkey). We received support from Firat University research funding for this study (number: TF.11.75).en_US
dc.item-language.isoengen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleNeuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhageen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorAlataş, Ömer Doğan
dc.contributor.institutionauthorAcar, Ethem
dc.identifier.doi10.1097/MD.0000000000002007
dc.identifier.volume94en_US
dc.identifier.issue45en_US
dc.relation.journalMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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