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dc.contributor.authorKılınç, Cem Yalın
dc.contributor.authorÖzcan, Selahattin
dc.contributor.authorAcar, Ethem
dc.contributor.authorTiftikçi, Uğur
dc.contributor.authorAykut, Serkan
dc.contributor.authorKılınç, Barış
dc.date.accessioned2020-11-20T15:06:53Z
dc.date.available2020-11-20T15:06:53Z
dc.date.issued2015
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.urihttps://hdl.handle.net/20.500.12809/3183
dc.descriptionWOS: 000375337000012en_US
dc.description.abstractIntroduction: Fracture healing is still one of the most important problems in orthopedic surgery clinics. Alcohol consumption, smoking, systemic disorders, and different drugs are among the factors that diminish fracture healing. Sildenafil citrate may enhance bone healing speed as it has known effects of increasing the blood supply to the tissues. Materials and methods: 36 male, Wistar-Albino rats were randomly divided into two groups as the control group and sildenafil group. A retrograde intramedullary Kirschner (K)-wire was inserted, and then standard closed shaft fracture was established with the use of a three-point bending system. Sildenafil was given orally to the sildenafil group after production of fracture. Each group was subdivided into two groups; seventeen rats were killed at the first week (Control Group A; Sildenafil Group C) and the other seventeen rats at the fourth week (Control Group B; Sildenafil Group D). Results: At the end of the first week, the results of control group (B) was not statistically significant but trended to have a better histological score, with a median grade of 5 (range: 2-5), than the sildenafil group (D), with a median grade of 3.5 (range: 2-5) (p=0.16). At the end of the fourth week, histological callus formation was found to be significantly superior in the sildenafil group, with a median grade of 8 (5-9), than in the control group, with a median grade of 5 (5-7) (p=0.02). The difference between the control and experimental groups as determined radiographically was not significant at both 1 and 4 weeks, respectively. Conclusions: The microscopic results of this study indicate that sildenafil might have dual effects on fracture healing. It accelerates the bone healing in the repair phase, where it has a trend to have some suppressive effects on the inflammatory phase.en_US
dc.item-language.isoengen_US
dc.publisherCarbone Editoreen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFracture Healingen_US
dc.subjectSildenafilen_US
dc.subjectBone Histologyen_US
dc.titleEFFECTS OF SILDENAFIL ON THE INFLAMMATORY AND REPAIR PHASE OF BONE HEALING SPEED IN A RAT MODELen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKılınç, Cem Yalın
dc.contributor.institutionauthorAcar, Ethem
dc.identifier.volume31en_US
dc.identifier.issue6en_US
dc.identifier.startpage1203en_US
dc.identifier.endpage1208en_US
dc.relation.journalActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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