Basit öğe kaydını göster

dc.contributor.authorSibai, Mustafa
dc.contributor.authorAltuntaş, Ebru
dc.contributor.authorYıldırım, Berna
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorYıldırım, Süleyman
dc.contributor.authorDemircan, Turan
dc.date.accessioned2020-11-20T14:30:03Z
dc.date.available2020-11-20T14:30:03Z
dc.date.issued2020
dc.identifier.issn1536-2310
dc.identifier.issn1557-8100
dc.identifier.urihttps://doi.org/10.1089/omi.2020.0116
dc.identifier.urihttps://hdl.handle.net/20.500.12809/328
dc.descriptionYıldırım, Berna/0000-0002-4479-2586en_US
dc.descriptionWOS: 000568095500001en_US
dc.descriptionPubMed ID: 32907488en_US
dc.description.abstractWith a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the blind mole-rat (Spalax leucodon), a subterranean mammalian, has emerged as an exceptional model organism due to its astonishing features such as remarkable longevity, hypoxia and hypercapnia tolerance, and cancer resistance. The microbiome has been found to be a vital parameter for cellular physiology and it is safe to assume that it has an impact on life expectancy. Although the unique characteristics ofSpalaxmake it an ideal experimental model for longevity research, there is limited knowledge of the bacterial composition ofSpalaxmicrobiome, which limits its in-depth utilization. In this study, using 16S rRNA amplicon sequencing, we report the gut and skin bacterial structure ofSpalaxfor the first time. The diversity between fecal and skin samples was manifested in the distant clustering, as revealed by beta diversity analysis. Importantly, the longevity-linked Muribaculaceae bacterial family was found to be the dominating bacterial taxa inSpalaxfecal samples. These new findings contribute toward further development ofSpalaxas a model for longevity research and potential linkages between microbiome composition and longevity.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID) Office of Cyber Infrastructure and Computational Biology (OCICB) in Bethesda, MDen_US
dc.description.sponsorshipThis study used the Nephele platform from the National Institute of Allergy and Infectious Diseases (NIAID) Office of Cyber Infrastructure and Computational Biology (OCICB) in Bethesda, MD.en_US
dc.item-language.isoengen_US
dc.publisherMary Ann Liebert, Incen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrobiomeen_US
dc.subjectLongevityen_US
dc.subjectAging Researchen_US
dc.subjectSpalaxen_US
dc.subjectMuribaculaceaeen_US
dc.subject16S Rrna Sequencingen_US
dc.titleMicrobiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living RodentSpalax leucodonen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorDemircan, Turan
dc.identifier.doi10.1089/omi.2020.0116
dc.identifier.volume24en_US
dc.identifier.issue10en_US
dc.identifier.startpage592en_US
dc.identifier.endpage601en_US
dc.relation.journalOmics-A Journal of Integrative Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster