dc.contributor.author | Ceylan, Özgür | |
dc.contributor.author | Karakuş, Hatice | |
dc.contributor.author | Çiçek, Hüseyin | |
dc.date.accessioned | 2020-11-20T14:39:21Z | |
dc.date.available | 2020-11-20T14:39:21Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0885-4513 | |
dc.identifier.issn | 1470-8744 | |
dc.identifier.uri | https://doi.org/10.1002/bab.1991 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12809/386 | |
dc.description | 0000-0002-1865-1093; | en_US |
dc.description | WOS: 000554351800001 | en_US |
dc.description | PubMed ID: 32701174 | en_US |
dc.description.abstract | In this study, a novel pH-sensitive hydrogel beads that is based on gelatin/sodium alginate/chitosan (GEL/SA/CS) loaded with propolis ethanolic extracts (PE) were synthesized. The swelling behavior of GEL/SA/CS hydrogel beads was studied in different pH solutions and compared with unloaded CS (GEL/SA) hydrogel beads. Thein vitrorelease studies have been revealed using four different pH (1.3, 5.0, 6.0, and 6.8), a saliva environment (pH 6.8), a simulated gastric fluid (SGF) (pH 1.3), and a simulated intestinal fluid (SIF) (pH 6.8) to simulate the physiological conditions in gastrointestinal (GI) tract. Propolis-loaded hydrogel beads were found to be stable at pH 1.3, 5.0, 6.0, simulated saliva, SGF, and SIF mediums, whereas the beads lose their stability at pH 6.8 buffer solution. Tested microorganisms displayed greater sensitivity to PE-loaded hydrogel beads compared with pure propolis. Contrary to antimicrobial activity results, antibiofilm activity results of PE-loaded GEL/SA and GEL/SA/CS hydrogel beads were found at low levels. According to the obtained results, the propolis-loaded GEL/SA/CS hydrogel beads synthesized within this study can be used in the treatment of GI tract diseases such as oral mucositis, gastric ulcer, ulcerative colitis, and GI cancer, as controlled releasing carriers of propolis. | en_US |
dc.description.sponsorship | Scientific Research Projects Office of Mugla Sitki Kocman UniversityMugla Sitki Kocman University [BAP 2013/139] | en_US |
dc.description.sponsorship | This study is a part of a MSc thesis and supported by Scientific Research Projects Office of Mugla Sitki Kocman University under BAP 2013/139 project number. | en_US |
dc.item-language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.item-rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antibiofilm | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Biopolymer | en_US |
dc.subject | Drug Carrier | en_US |
dc.subject | Gastrointestinal Tract | en_US |
dc.subject | Propolis | en_US |
dc.title | Design andin vitroantibiofilm activity of propolis diffusion-controlled biopolymers | en_US |
dc.item-type | article | en_US |
dc.contributor.department | MÜ, Fen Fakültesi, Kimya Bölümü | en_US |
dc.contributor.institutionauthor | Ceylan, Özgür | |
dc.contributor.institutionauthor | Karakuş, Hatice | |
dc.contributor.institutionauthor | Çiçek, Hüseyin | |
dc.identifier.doi | 10.1002/bab.1991 | |
dc.relation.journal | Biotechnology and Applied Biochemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |