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dc.contributor.authorCeylan, Özgür
dc.contributor.authorKarakuş, Hatice
dc.contributor.authorÇiçek, Hüseyin
dc.date.accessioned2020-11-20T14:39:21Z
dc.date.available2020-11-20T14:39:21Z
dc.date.issued2020
dc.identifier.issn0885-4513
dc.identifier.issn1470-8744
dc.identifier.urihttps://doi.org/10.1002/bab.1991
dc.identifier.urihttps://hdl.handle.net/20.500.12809/386
dc.description0000-0002-1865-1093;en_US
dc.descriptionWOS: 000554351800001en_US
dc.descriptionPubMed ID: 32701174en_US
dc.description.abstractIn this study, a novel pH-sensitive hydrogel beads that is based on gelatin/sodium alginate/chitosan (GEL/SA/CS) loaded with propolis ethanolic extracts (PE) were synthesized. The swelling behavior of GEL/SA/CS hydrogel beads was studied in different pH solutions and compared with unloaded CS (GEL/SA) hydrogel beads. Thein vitrorelease studies have been revealed using four different pH (1.3, 5.0, 6.0, and 6.8), a saliva environment (pH 6.8), a simulated gastric fluid (SGF) (pH 1.3), and a simulated intestinal fluid (SIF) (pH 6.8) to simulate the physiological conditions in gastrointestinal (GI) tract. Propolis-loaded hydrogel beads were found to be stable at pH 1.3, 5.0, 6.0, simulated saliva, SGF, and SIF mediums, whereas the beads lose their stability at pH 6.8 buffer solution. Tested microorganisms displayed greater sensitivity to PE-loaded hydrogel beads compared with pure propolis. Contrary to antimicrobial activity results, antibiofilm activity results of PE-loaded GEL/SA and GEL/SA/CS hydrogel beads were found at low levels. According to the obtained results, the propolis-loaded GEL/SA/CS hydrogel beads synthesized within this study can be used in the treatment of GI tract diseases such as oral mucositis, gastric ulcer, ulcerative colitis, and GI cancer, as controlled releasing carriers of propolis.en_US
dc.description.sponsorshipScientific Research Projects Office of Mugla Sitki Kocman UniversityMugla Sitki Kocman University [BAP 2013/139]en_US
dc.description.sponsorshipThis study is a part of a MSc thesis and supported by Scientific Research Projects Office of Mugla Sitki Kocman University under BAP 2013/139 project number.en_US
dc.item-language.isoengen_US
dc.publisherWileyen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibiofilmen_US
dc.subjectAntimicrobialen_US
dc.subjectBiopolymeren_US
dc.subjectDrug Carrieren_US
dc.subjectGastrointestinal Tracten_US
dc.subjectPropolisen_US
dc.titleDesign andin vitroantibiofilm activity of propolis diffusion-controlled biopolymersen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Kimya Bölümüen_US
dc.contributor.institutionauthorCeylan, Özgür
dc.contributor.institutionauthorKarakuş, Hatice
dc.contributor.institutionauthorÇiçek, Hüseyin
dc.identifier.doi10.1002/bab.1991
dc.relation.journalBiotechnology and Applied Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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