| dc.contributor.author | Çevik, Serdar | |
| dc.contributor.author | Timur, Suna | |
| dc.contributor.author | Anık, Ülkü | |
| dc.date.accessioned | 2020-11-20T16:23:19Z | |
| dc.date.available | 2020-11-20T16:23:19Z | |
| dc.date.issued | 2012 | |
| dc.identifier.issn | 2046-2069 | |
| dc.identifier.uri | https://doi.org/10.1039/c2ra01282k | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12809/4242 | |
| dc.description | WOS: 000304327300040 | en_US |
| dc.description.abstract | This work constitutes the first biocentri-voltammetric application for acetylcholinesterase (AChE) activity assay. After the optimization of working conditions like reaction time, centrifugation speed and time and enzyme amount, the analytical characteristics were investigated. As a result, the linear range of 1.0-350 mu M was obtained with an equation of y = 0.0004x + 0.0163. The correlation coefficient is equal to (R-2) 0.99 +/- 0.001815 (n = 3) and the RSD value was calculated as 3.6% (n = 4). Then Donepezil-based drug analysis was also conducted by using the developed method and an inhibition of 80% was calculated. | en_US |
| dc.description.sponsorship | Technical and Scientific Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109T885] | en_US |
| dc.description.sponsorship | The grant from The Technical and Scientific Council of Turkey (TUBITAK) Project no: 109T885 is gratefully acknowledged. | en_US |
| dc.item-language.iso | eng | en_US |
| dc.publisher | Royal Soc Chemistry | en_US |
| dc.item-rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Biocentri-voltammetry for the enzyme assay: a model study | en_US |
| dc.item-type | article | en_US |
| dc.contributor.department | MÜ, Fen Fakültesi, Kimya Bölümü | en_US |
| dc.contributor.institutionauthor | Çevik, Serdar | |
| dc.contributor.institutionauthor | Anık, Ülkü | |
| dc.identifier.doi | 10.1039/c2ra01282k | |
| dc.identifier.volume | 2 | en_US |
| dc.identifier.issue | 10 | en_US |
| dc.identifier.startpage | 4299 | en_US |
| dc.identifier.endpage | 4303 | en_US |
| dc.relation.journal | Rsc Advances | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
