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dc.contributor.authorErarslan, Elife
dc.contributor.authorEkiz, Fuat
dc.contributor.authorUz, Burak
dc.contributor.authorKoca, Cemile
dc.contributor.authorTurkcu, Ummuhani Ozel
dc.contributor.authorBayrak, Reyhan
dc.contributor.authorDelibasi, Tuncay
dc.date.accessioned2020-11-20T16:33:42Z
dc.date.available2020-11-20T16:33:42Z
dc.date.issued2011
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.urihttps://doi.org/10.3109/01480545.2010.483519
dc.identifier.urihttps://hdl.handle.net/20.500.12809/4459
dc.descriptionWOS: 000284881100005en_US
dc.descriptionPubMed ID: 20954827en_US
dc.description.abstractCyclosporine A (CsA) is a potent immunosuppressive agent used for organ transplantations and various autoimmune disorders. However, hepatotoxicity due to CsA remains one of the major side effects. The use of antioxidants reduces the adverse effects of CsA. The aim of this study was to determine the protective effects of erdosteine on CsA-induced liver injury through tissue oxidant/antioxidant parameters and to evaluate light microscopic alterations in rat-liver tissues. Rats were randomly divided into four experimental groups: The control group received sunflower oil (2 mL/kg/day, per orally; p.o.), while the other groups were treated with CsA (25 mg/kg/day, p.o.) or erdosteine (10 mg/kg/day, p.o.) or CsA+erdosteine, respectively. Serum aspartate aminotransferase and alanine aminotransferase levels, tissue malondialdehyde and nitric oxide levels, and superoxide dismutase, glutathione peroxidase and catalase enzyme activities were measured. Histological examination was performed. CsA caused a significant deterioration in the hepatic function tests, morphology, and gave rise to severe oxidative stress in the liver. Erdostein significantly improved the functional and histological parameters and attenuated the oxidative stresss induced by CsA. Erdostein protects liver tissue against oxygen free radicals and prevents hepatic dysfunction and morphological abnormalities associated with chronic CsA administration.en_US
dc.item-language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErdosteineen_US
dc.subjectCyclosporine Aen_US
dc.subjectHepatotoxicityen_US
dc.subjectAntioxidant Actionen_US
dc.titleEffects of erdosteine on cyclosporine-A-induced hepatotoxicity in ratsen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Erarslan, Elife] Fatih Univ, Sch Med, Dept Gastroenterol, Ankara, Turkey -- [Ekiz, Fuat] Diskapi Yildirim Beyazit Educ & Res Hosp, Dept Gastroenterol, Ankara, Turkey -- [Uz, Burak] Fatih Univ, Sch Med, Dept Internal Med, Ankara, Turkey -- [Koca, Cemile] Fatih Univ, Sch Med, Dept Clin Biochem, Ankara, Turkey -- [Turkcu, Ummuhani Ozel] Mugla Univ, Mugla Sch Hlth Sci, Mugla, Turkey -- [Bayrak, Reyhan] Fatih Univ, Sch Med, Dept Pathol, Ankara, Turkeyen_US
dc.identifier.doi10.3109/01480545.2010.483519
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.startpage32en_US
dc.identifier.endpage37en_US
dc.relation.journalDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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