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dc.contributor.authorErcan, G.
dc.contributor.authorYigitturk, G.
dc.contributor.authorErbas, O.
dc.date.accessioned2020-11-20T17:17:16Z
dc.date.available2020-11-20T17:17:16Z
dc.date.issued2019
dc.identifier.issn0102-8650
dc.identifier.urihttps://doi.org/10.1590/s0102-865020190120000004
dc.identifier.urihttps://hdl.handle.net/20.500.12809/6348
dc.descriptionPubMed ID: 32074166en_US
dc.description.abstractPurpose: To examine the therapeutic effect of external adenosine on an acetic acid-induced acute ulcerative colitis model in rats. Methods: Thirty male mature rats were divided into three groups as control, acute colitis (AC) and AC+adenosine group (AC+AD). AC was induced by rectal administration of 4% acetic acid (AA). 5mg/kg/day adenosine was performed i.p for 4 weeks to AC+AD group. Rectum and colon were excised for microscopic and histopathological histopathologic evaluations, and immunohistochemical analysis of nuclear factor kappa B (NF-kB). Blood samples were collected for biochemical detection of TNF-?, Pentraxin-3 and malondialdehyde (MDA) levels. Results: AC group had generalized hyperemia and hemorrhage with increased macroscopic and histopathological scores compared with control (P <0.0001) while adenosine treatment decreased these scores significantly (P <0.001), with reduced distribution of disrupted epithelium, leukocyte infiltrates, and focal hemorrhage. AC group showed significantly increased immunoexpression of NF-kB in rectum, plasma and tissue levels of TNF-?, plasma Pentraxin-3 and MDA levels (P <0.0001) while adenosine reduced these levels (P < 0.05). Conclusion: Adenosine appears to promote healing of colon and rectum exposed to AA-induced AC, suggesting a boosting effect of adenosine on the intestinal immune system to cure ulcerative colitis. © 2019, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.en_US
dc.item-language.isoengen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColitisen_US
dc.subjectNF-kappa Ben_US
dc.subjectRatsen_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.subjectUlcerativeen_US
dc.titleTherapeutic effect of adenosine on experimentally induced acute ulcerative colitis model in ratsen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTempErcan, G., Department of General Surgery, University of Health Science Bagcilar Training and Research Hospital, Istanbul, Turkey; Yigitturk, G., Department of Histology and Embryology, Faculty of Medicine of Mugla Sitki Kocaman University, Mugla, Turkey; Erbas, O., Department of Physiology, Faculty of Medicine of Demiroglu Bilim University, Istanbul, Turkeyen_US
dc.identifier.doi10.1590/s0102-865020190120000004
dc.identifier.volume34en_US
dc.identifier.issue12en_US
dc.relation.journalActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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