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dc.contributor.authorBaygar, Tuba
dc.date.accessioned2020-11-20T14:40:15Z
dc.date.available2020-11-20T14:40:15Z
dc.date.issued2020
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://doi.org/10.3906/sag-1906-48
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TXpNME16QTVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12809/697
dc.descriptionWOS: 000514283600034en_US
dc.descriptionPubMed ID: 31655520en_US
dc.description.abstractBackground/aim: Bacterial adherence to a suture material is one of the main causes of surgical site infections. An antibacterial suture material with enhanced wound healing function may protect the surgical site from infections. Thus, the present study aimed to investigate the synergistic effect of propolis and biogenic metallic nanoparticles when combined with silk sutures for biomedical use. Materials and methods: Silver nanoparticle (AgNP) synthesis was carried out via a microbial-mediated biological route and impregnated on propolis-loaded silk sutures using an in situ process. Silk sutures fabricated with propolis and biosynthesized AgNPs (bioAgNP-propolis-coated sutures) were intensively characterized using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The antibacterial characteristics of the bioAgNP-propolis-coated sutures were evaluated using the agar plate method. The biocompatibility of the bioAgNP-propolis-coated sutures was evaluated using 3T3 fibroblast cells, and their wound-healing potential was also investigated. Results: BioAgNP-propolis-coated sutures displayed potent antibacterial activity against pathogenic gram-negative and gram-positive bacteria, Escherichia coli and Staphylococcus aureus, respectively. BioAgNP-propolis-coated silk sutures were found to be biocompatible with 3T3 fibroblast cell culture. In vitro wound healing scratch assay also demonstrated that the extract of bioAgNP-propolis-coated sutures stimulated the 3T3 fibroblasts' cell proliferation. Conclusion: Coating the silk sutures with propolis and biogenic AgNPs gave an effective antibacterial capacity to surgical sutures besides providing biocompatibility and wound healing activity.en_US
dc.item-language.isoengen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPropolisen_US
dc.subjectSilver Nanoparticleen_US
dc.subjectSutureen_US
dc.subjectAntibacterialen_US
dc.subjectWound Healingen_US
dc.subjectCytotoxicityen_US
dc.titleCharacterization of silk sutures coated with propolis and biogenic silver nanoparticles (AgNPs); an eco-friendly solution with wound healing potential against surgical site infections (SSIs)en_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Su Ürünleri Fakültesi, Su Ürünleri Avlama Ve İşleme Teknolojisi Bölümüen_US
dc.contributor.institutionauthorBaygar, Tuba
dc.identifier.doi10.3906/sag-1906-48
dc.identifier.volume50en_US
dc.identifier.issue1en_US
dc.identifier.startpage258en_US
dc.identifier.endpage266en_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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