The expression of TROP2 in the urothelial carcinomas of the upper urinary system

Abstract

ConferenceUpper urinary system urothelial carcinomas (UUSUC), including renal pelvis and ureteral tumours, are rare tumours. Many prognostic and predictive factors are defined in UUSUCs. The transmembrane glycoprotein Trop2 is highly expressed in many cancers, and has different expression profile in certain normal tissues. Trop2 overexpression is associated with decreased patient survival, tumour aggressiveness and metastasis in many cancers. We aimed to determine the characteristic features of UUSUCs and to evaluate the relation of clinicopathological parameters with TROP2 expression.