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dc.contributor.authorKeelo, Rihab Mudhafar Ali Hammood
dc.contributor.authorElbe, Hülya
dc.contributor.authorBiçer, Yasemin
dc.contributor.authorYiğittürk, Gürkan
dc.contributor.authorKoca, Oğuzhan
dc.contributor.authorKarayakalı, Melike
dc.contributor.authorAcar, Derya
dc.contributor.authorAltınöz, Eyüp
dc.date.accessioned2021-11-11T08:03:37Z
dc.date.available2021-11-11T08:03:37Z
dc.date.issued2022en_US
dc.identifier.issn00092797
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2021.109733
dc.identifier.urihttps://hdl.handle.net/20.500.12809/9636
dc.description.abstractOne of the most common complications of diabetes is diabetic nephropathy (DN). Uncontrolled hyperglycemia leads to histopathologic alterations in the kidney that prevent normal renal function. This study aimed to explore the effects of crocin treatment via virtue of its numerous beneficial properties in streptozotocin-induced pinealectomized diabetic rats. The pinealectomy procedure was conducted on the first day of the study. On the 30th day following pinealectomy, streptozotocin (STZ) (50 mg/kg) was administered intraperitoneally in Wistar rats for induction of diabetes. Diabetes was confirmed on the 3rd day following STZ administration by determining the glucose levels. Daily crocin treatment intraperitoneally for 15 days (50 mg/kg) ameliorated impaired renal oxidant/antioxidant balance, reduced TGF-β1 immuno-staining around tubules, and promoted improvement of renal architecture. Moreover, crocin administration improved altered renal function parameters, including serum Cr and BUN, and also increased creatinine clearance. In conclusion, the protective effects of crocin on diabetic nephropathy might be associated with its powerful antioxidant properties, its ability to improve tissue antioxidant status, and its ability to prevent inflammatory pathways.en_US
dc.item-language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.cbi.2021.109733en_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPinealectomyen_US
dc.subjectDiabetesen_US
dc.subjectCrocinen_US
dc.subjectMDAen_US
dc.subjectTGF-β1en_US
dc.subjectROSen_US
dc.titleTreatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic ratsen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorElbe, Hülya
dc.contributor.institutionauthorYiğittürk, Gürkan
dc.identifier.volume351en_US
dc.relation.journalChemico-Biological Interactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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