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Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats
Abdulkareem Aljumaily, Sara Asaad; Demir, Mehmet; Elbe, Hülya; Yiğittürk, Gürkan; Biçer, Yasemin; Altınöz, Eyüp (Springer, 2021)Doxorubicin (DOX) is a well-known chemotherapeutic drug for most malignancies including breast cancer and leukemia whilst the usage of DOX is limited owing to its cardiotoxicity. In the present study, we aimed to investigate ... -
Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats
Karayakalı, Melike; Altınöz, Eyüp; Elbe, Hülya; Koca, Oğuzhan; Önal, Melike Özgül; Biçer, Yasemin; Demir, Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Diabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence that leads to significant morbidity and mortality. The liver plays a vital role in glycemic regulation in physiological and ... -
THE EFFECT OF SAFFRON (ITS ACTIVE CONSTITUENT, CROCIN) ON THE CARDIOVASCULAR COMPLICATION AND DYSLIPIDEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Altınöz, Eyüp; Taşkın, Emre; Öner, Zulal; Elbe, Hülya; Arslan, Belkis Atasever (African Networks Ethnomedicines, 2015)Background: Diabetes mellitus (DM) causes serious complications such as coronary heart disease, atherosclerosis, nephropathy, retinopathy and neuropathy. Materials and Methods: Rats were randomly divided into three groups, ... -
Effects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarction
Demir, Mehmet; Altınöz, Eyüp; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Karayakalı, Melike (Taylor and Francis Ltd., 2021)The present study aimed to analyze the effects of pinealectomy and crocin treatment in isoproterenol-induced myocardial damage. Seventy rats were divided into seven groups: control, sham control, pinealectomy (PNX), ... -
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis
Haqi Ballur, Arwa Fadil; Altınöz, Eyüp; Yiğittürk, Gürkan; Özgül Önal, Melike; Elbe, Hülya (Springer, 2022)Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous ... -
Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress
Altınöz, Eyüp; Öner, Zulal; Elbe, Hülya; Üremiş, Nuray; Üremiş, Muhammed (Taylor and Francis Ltd., 2021)The aim of the present study was to investigate the therapeutic and protective effects of linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were divided into 8 groups as follows; Control, ... -
Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats
Biçer, Yasemin; Elbe, Hülya; Karayakalı, Melike; Yigittürk, Gürkan; Yılmaz, Ümit; Cengil, Osman; Al Gburi, Mohammed Raed Abdullah; Altınöz, Eyüp (Elsevier B.V., 2022)The current study aimed to evaluate the neuroprotective effect of exogenous melatonin against acrylamide (ACR)-induced oxidative stress and inflammatory and apoptotic responses in the brain tissues in pinealectomized rats ... -
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by alpha-naphthylthiourea
Al Gburi, Mohammed Raed Abdullah; Altınöz, Eyüp; Elbe, Hülya; Yılmaz, ümit; Yılmaz, Nesibe; Karayakalı, Melike; Önal, Melike Özgül (TAYLOR & FRANCIS LTD, 2022)We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats. Seventy ... -
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation
Öztürk, İpek; Elbe, Hülya; Biçer, Yasemin; Karayakalı, Melike; Özgul-Önal, Melike; Altınöz, Eyüp (Elsevier Ltd, 2023)Acrylamide (AA) is formed in some foods by the cooking process at high temperatures, and it could be a carcinogen in humans and rodents. The purpose of the current study was to reveal the possible protective effects of ... -
Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats
Keelo, Rihab Mudhafar Ali Hammood; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Koca, Oğuzhan; Karayakalı, Melike; Acar, Derya; Altınöz, Eyüp (Elsevier, 2022)One of the most common complications of diabetes is diabetic nephropathy (DN). Uncontrolled hyperglycemia leads to histopathologic alterations in the kidney that prevent normal renal function. This study aimed to explore ...
