Yazar "Edgünlü, Tuba" için listeleme
-
Assessment of COL1A1 and MMP9 expression in patients with dermatochalasis
Türkcü, Ümmühani Özel; Yuksel, Nilay; Akcay, Emine; Ayan, Berna; Kuru, Oktay; Edgünlü, Tuba; Tosun, Kürşad (Springer, 2020)Purpose Dermatochalasis is a clinical condition characterized by loss of elasticity of eyelid skin and soft tissue, which typically affects the elderly population. The aim of this study is to investigate the mRNA expression ... -
Association of SNAP-25 Gene Ddel and Mnll Polymorphisms with Adult Attention Deficit Hyperactivity Disorder
Herken, Hasan; Erdal, Mehmet Emin; Kenar, Ayşe Nur Inci; Ünal, Gonca Ayşe; Çakaloz, Burcu; Ay, Mustafa Ertan; Şengül, Cem; Edgünlü, Tuba (Korean Neuropsychiatric Assoc, 2014)Objective The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. ... -
Association of Synapsin III Gene with Adult Attention Deficit Hyperactivity Disorder
İnci Kenar, Ayşe Nur; Edgünlü, Tuba; Herken, Hasan; Erdal, Mehmet Emin (Mary Ann Liebert, Inc, 2013)It was aimed to investigate the association of the synapsin III gene -196 G> A and -631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One ... -
The effect of FOXO gene family variants and global DNA methylation on RRMS disease
Edgünlü, Tuba; Ünal, Yasemin; Karakaş Çelik, Sevim; Genç, Öyküm; Emre, Ufuk; Kutlu, Gülnihal (Wiley, 2019)5th Congress of the European-Academy-of-Neurology -
Effects of adipose and bone marrow-derived mesenchymal stem cells on vaginal atrophy in a rat menopause model
Kasap, Burcu; Kasap, Şükrü; Vatansever, Seda; Kendirci, Remziye; Yilmaz, Osman; Çalışır, Meryem; Akın, Melike Nur; Edgünlü, Tuba (Elsevier, 2019)Background & objectives: Vaginal atrophy is characterized by thinning of vaginal epithelial layers and decreased local blood flow. We aimed to evaluate the regenerative effects of Adipose derived mesenchymal stem cells ... -
Evaluation of mTOR Activity in COPD Patients with Emphysema
Oral Tapan, Özge; Tapan, Utku; Edgünlü, Tuba; Doğan, Emrah (College of Physicians and Surgeons Pakistan, 2022)Objective: To evaluate the function of the mammalian target of the rapamycin (mTOR) pathway in chronic obstructive pulmonary disease (COPD) patients with emphysema. Study Design: Observational study. Place and Duration of ... -
Evaluation of serum trail level and DR4 gene variants as biomarkers for vitiligo patients
Edgünlü, Tuba; Tekin, N. Solak; Türkcü, Ümmühani Özel; Karakaş-Çelik, S.; Urhan-Küçük, M.; Tekin, L. (Wiley-Blackwell, 2016)[No abstract available] -
Exploration of Potential miRNA Biomarkers and Prediction for Ovarian Cancer Using Artificial Intelligence
Hamidi, Farzaneh; Gilani, Neda; Belaghi, Reza Arabi; Sarbakhsh, Parvin; Edgünlü, Tuba; Santaguida, Pasqualina (MedGen, 2021)Ovarian cancer is the second most dangerous gynecologic cancer with a high mortality rate. The classification of gene expression data from high-dimensional and small-sample gene expression data is a challenging task. The ... -
GPR30 Gene Polymorphisms Are Associated with Gynecomastia Risk in Adolescents
Korkmaz, Hüseyin Anıl; Edgünlü, Tuba; Eren, Erdal; Demir, Korcan; Çakır, Esra Deniz Papatya; Çelik, Sevim Karakaş; Özkan, Behzat (Karger, 2015)Aim: The G protein-coupled receptor, GPR30, which is a third estrogen receptor, has been shown to mediate estrogenic effects on the essential features of human breast cancer cells. The aim of this study was to evaluate the ... -
Homozygous Ala65Pro Mutation with V89L Polymorphism in SRD5A2 Deficiency
Eren, Erdal; Edgünlü, Tuba; Asut, Emre; Çelik, Sevim Karakaş (Galenos Yayincilik, 2016)Objective: Deficiency of steroid 5-alpha reductase type 2 (5 alpha RD2) is a rare autosomal recessive disorder caused by mutations in the SRD5A2 gene. A defect in the 5-alpha reductase enzyme, which ensures conversion of ... -
Identifying Potential miRNA Biomarkers for Gastric Cancer Diagnosis Using Machine Learning Variable Selection Approach
Gialini, Neda; Belaghi, Reza Arabi; Aftabi, Younes; Faramarzi, Elnaz; Edgünlü, Tuba (Frontiers Media S.A., 2022)Aim: This study aimed to accurately identification of potential miRNAs for gastric cancer (GC) diagnosis at the early stages of the disease. Methods: We used GSE106817 data with 2,566 miRNAs to train the machine learning ... -
Investigation of genetic variations of IL17 for vitiligo disease
Çelik, Sevim Karakaş; Tekin, Nilgün Solak; Genç, Günes Çakmak; Edgünlü, Tuba; Türkcü, Ümmühani Özel; Dursun, Ahmet (Kuwait Medical Assoc, 2019)Objective: Vitiligo is a disorder of pigmentation characterized by the presence of depigmented skin macules due to a chronic and progressive loss of melanocytes from the cutaneous epidermis. Among many different etiologic ... -
Lack of association between sirtuin gene variants and endometrial cancer
Tekin, Leyla; Edgünlü, Tuba; Çelik, Sevim Karakaş (Elsevier Science Bv, 2019)Cancer of the endometrium is the most common gynecological cancer in women. The pathophysiology of the disease has not yet been clearly defined, and the pathways leading to endometrial carcinoma are not fully understood. ... -
miR-181a-5p is a potential candidate epigenetic biomarker in multiple sclerosis
Edgünlü, Tuba; Görücü Yılmaz, Şenay; Emre, Ufuk; Taşdelen, Bahar; Kuru, Oktay; Kutlu, Gülnihal; Erdal, Mehmet Emin (NLM (Medline), 2022)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression of microRNAs (miRNAs) plays an important role in MS ... -
miR-181a-5p is a potential candidate epigenetic biomarker in sclerosis
Edgünlü, Tuba; Görücü Yılmaz, Şenay; Emre, Ufuk; Taşdelen, Bahar; Kuru, Oktay; Kutlu, Gülnihal; Erdal, Mehmet Emin (CANADIAN SCIENCE PUBLISHING, 2022)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression of microRNAs (miRNAs) plays an important role in MS ... -
Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder
Barış, Remzi Oğuz; Şahin, Nilfer; Bilgiç, Ayşegül Demirtaş; Edgünlü, Tuba; Özdemir, Çilem (Springer Science and Business Media Deutschland GmbH, 2023)Background: Defects in neurotransmission and synaptogenesis are noteworthy in the pathogenesis of ASD. Synapsin III (SYN III) is defined as a synaptic vesicle protein that plays an important role in synaptogenesis and ... -
Novel Fructose-1,6-bisphosphatase Gene Mutation in Two Siblings
Eren, Erdal; Edgünlü, Tuba; Abuhandan, Mahmut; Yetkin, İlhan (Mary Ann Liebert, Inc, 2013)Fructose-1,6-bisphosphatase (FBPase) deficiency is an autosomal, recessively inherited disease that progresses with severe hypoglycemia, and metabolic attacks result in a defect in gluconeogenesis. If not appropriately ... -
The role of adropin, salusin-α, netrin-1, and nesfatin-1 in endometriosis and their association with insulin resistance
Akbaba, Eren; Sezgin, Burak; Edgünlü, Tuba (GALENOS YAYINCILIK, 2021)Objective: The pathogenesis of endometriosis has not been clearly explained. Inflammatory factors of ectopic implantation and the growth of ectopic endometrial cells have been subjects of major interest. The number of ... -
Role of Leptin (rs7799039) and Leptin Receptor (rs1137101) Gene Polymorphisms in the Development of Uterine Leiomyoma
Turhan, Nilgün Öztürk; Edgünlü, Tuba; Akbaba, Eren; Deveer, Rüya; Kasap, Burcu (Kuwait Medical Assoc, 2017)Objective: To evaluate whether there is an association between leptin (rs7799039) and leptin receptor (rs1137101) gene polymorphisms and risk of Uterine Leiomyoma (ULM) development Design: Controlled prospective study ... -
A study of the correlation between the serum Latexin levels and the mTORC subunits Raptor and Rictor in the molecular pathogenesis of chronic lymphocytic leukemia
Pektaş, Gökhan; Karakuş, Volkan; Çetin, Deniz; Edgünlü, Tuba (Turaz Bilim, 2021)Abstract: Hematopoietic stem cells (HSCs) ensure the lifelong production of blood cells throughout a lifetime. Latexin (Lxn) is thought to have a tumor suppressor role and endogenously down-regulate the number of HSCs via ...
