Yazar "Erbaş, Oytun" için listeleme
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Anti-Inflammatory and Anti-Fibrotic Effects of Ursodeoxycholic Acid in Streptozocin-Induced Diabetic Rats
Canbolat, İsmail Polat; Yiğittürk, Gürkan; Erbaş, Oytun (Kocaeli Derince Eğitim ve Araştırma Hastanesi, 2020)INTRODUCTION: Diabetic cardiomyopathy is a consequence of free fatty acid oxidation, dysfunction in mitochondria, oxidative stress and diffuse myocardial fibrosis. We aimed to investigate the anti-inflammatory and anti-fibrotic ... -
Comparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Model
Kaya, Hüseyin; Sabah, Dündar; Keçeci, Burçin; Küçük, Levent; Erbaş, Oytun; Oltulu, Fatih; Taşkıran, Dilek (Taylor & Francis Inc, 2019)Aim of the study: Biologic reconstruction using tumor-bearing bone autografts devitalized by liquid nitrogen or extracorporeal irradiation (oncological sterilization) is a safe and effective method in musculoskeletal ... -
Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology
Özkul, Bahattin; Sever, İbrahim Halil; Yiğittürk, Gürkan; Elgörmüş, Çağrı Serdar; Gür, Seray Gizem; Erbaş, Oytun (Turkish Association of Trauma and Emergency Surgery (TATES), 2023)Background: Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate ... -
Demonstration of ameliorative effect of lacosamide: in a rat model of sepsis-induced critical illness polyneuropathy
Solmaz, Volkan; Aksoy, Durdane; Yılmaz, Mustafa; Eser, Enes; Erbaş, Oytun (Taylor & Francis Ltd, 2015)Objectives: Critical illness neuropathy (CIN) is a condition that may occur in diseases with severe systemic response, particularly in sepsis. The aim of this study is to investigate the potential anti-inflammatory and ... -
Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy
Karahan, Gökhan; Kaya, Hüseyin; Eyceyurt, Recep Selçuk; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun (Spandidos Publications, 2021)The aim of the present study was to investigate the effect of dexpanthenol on nerve healing following neurorrhaphy in lacerated peripheral nerves. A total of 30 mature Sprague Dawley rats were used. Surgical sciatic nerve ... -
Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia
Erdoğan, Mümin Alper; Kirazlar, Mehmet; Yiğittürk, Gürkan; Erbaş, Oytun (Springer, 2022)Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ... -
The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats
Bora, Saylav; Erdoğan, Mümin Alper; Yigittürk, Gürkan; Erbaş, Oytun; Parlak, İsmet (Humana Press Inc, 2018)The aim of this study was to evaluate the effects of metoprolol, lipid emulsion and MgSO4 which can be recommended for prevention of long QT that is one of the lethal consequences of amitriptyline intoxication. Thirty ... -
Effects of Methylene Blue on Ovarian Torsion - Detorsion Injury in a Rat Model
İlgen, Orkun; Hortu, İsmet; Özçeltik, Gökay; Yiğitturk, Gürkan; Erbaş, Oytun; Karadadaş, Nedim (Elsevier Science Inc, 2020)Study Objectives -
The efficacy of Aesculus hippocastanum seeds on diabetic nephropathy in a streptozotocin-induced diabetic rat model
Elmas, Onur; Erbaş, Oytun; Yiğittürk, Gürkan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Cytokines, such as transforming growth factor (TGF)-beta 1, and increased oxidative stress are considered to be responsible for the development of diabetic nephropathy. We hypothesized that Aesculus hippocastanum (AH) seeds ... -
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taşkın, Banu; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Alper, Sibel; Erbaş, Oytun (Hindawi, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease
Yigittürk, Gürkan; Bilal, Burçin; Kirazlar, Mehmet; Erdoğan, Mümin Alper; Erbaş, Oytun (Journal of Chemical Neuroanatomy, 2023)Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that primarily affects the motor system. Although there are several treatments available to alleviate PD symptoms, there is ... -
Levetiracetam attenuates rotenone-induced toxicity: A rat model of Parkinson's disease
Erbaş, Oytun; Yılmaz, Mustafa; Taşkıran, Dilek (Elsevier Science Bv, 2016)Levetiracetam (LEV), a second-generation anti-epileptic drug, is used for treatment of both focal and generalized epilepsy. Growing body of evidence suggests that LEV may have neuroprotective effects. The present study was ... -
Metoprolol and diltiazem ameliorate ziprasidone-induced prolonged corrected QT interval in rats
Erbaş, Oytun; Yılmaz, Mustafa (Sage Publications Inc, 2015)Ziprasidone, an atypical antipsychotic agent, has been shown to increase the corrected QT (QTc) interval in some patients. The aim of this study was to reveal the effects of metoprolol and diltiazem on ziprasidone drug-induced ... -
The neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathy
Yiğittürk, Gürkan; Erbaş, Oytun; Karabay Yavaşoğlu, Nefise Ülkü; Açıkgöz, Eda; Buhur, Aylin (Taylor and Francis Ltd., 2021)Diabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, the only effective treatments are blood glucose control and pain management. ... -
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats
Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun; Taşkıran, Dilek (TAYLOR & FRANCIS INC, 2021)Aim: Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ... -
Oxytocin inhibits pentylentetrazol-induced seizures in the rat
Erbaş, Oytun; Yılmaz, Mustafa; Korkmaz, Hüseyin Anıl; Bora, Saylav; Evren, Vedat; Peker, Gönül (Elsevier Science Inc, 2013)We aimed to reveal the anti-convulsant effects of oxytocin (OT) in pentylenetetrazol (PTZ)-induced seizures in rats. Thirty rats were randomly divided into 5 equal groups. Using stereotaxy, we implanted electroencephologram ... -
Protective effect of oxytocin on a methotrexate-induced ovarian toxicity model
Hortu, İsmet; Özçeltik, Gökay; Ergenoğlu, Ahmet Mete; Yiğittürk, Gürkan; Atasoy, Özüm; Erbaş, Oytun (Springer Heidelberg, 2020)Purpose Although cancer predominantly affects people at older ages, a substantial number of patients, like breast cancer patients, are diagnosed before they have completed their families or even before giving birth. ... -
The Protective Effects of Carvedilol on Diabetic Nephropathy in A Streptozotocin-Induced Diabetic Rat Model
Erdoğan, Mümin Alper; Yigittürk, Gürkan; Erbaş, Oytun (Wiley, 2019)[No abstract available] -
The Restorative Effect of Gallic Acid on the Experimental Sciatic Nerve Damage Model
Gürkan, Gökhan; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun (Korean Neurosurgical Society, 2021)Objective: Peripheral nerve injuries occur mostly as a result of mechanical trauma. Due to the microvascular deterioration in peripheral nerve damage, it becomes challenging to remove free oxygen radicals. Gallic acid is ... -
Short-term protective effect of octreotide on the lungs of rats with experimentally induced sepsis
Bora, Ejder Saylav; Erdoğan, Arife; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Çakır, Adem; Erbaş, Oytun (URKISH ASSOC TRAUMA EMERGENCY SURGERY, 2022)BACKGROUND: Acute respiratory distress syndrome is a devastating complication of severe sepsis. Preclinical models suggest that direct lung injury begins with attack to the lung epithelium, but indirect lung injury results ...
