Yazar "Gök, Müslüm" için listeleme
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Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease
Gök, Müslüm; Madrer, Nimrod; Zorbaz, Tamara; Bennett, Estelle R.; Greenberg, David; Bennett, David A.; Soreq, Hermona (PMC, 2022)Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) are involved in modulating cholinergic signaling, but their roles in Alzheimer's and Parkinson's diseases (AD and PD) remain unclear. We identified a higher ... -
Butyrylcholinesterase in lipid metabolism: A new outlook
Gök, Müslüm; Çicek, Çiğdem; Bodur, Ebru (WILEY, 2023)Cholinesterase enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are traditionally associated with the termination of acetylcholine mediated neural signaling. The fact that these ubiquitous enzymes are ... -
cAMP/PKA-CREB-BDNF signaling pathway in hippocampus of rats subjected to chemically-induced phenylketonuria
Çiçek, Çiğdem; çiçek, Çiğdem; Telkoparan-Akıllılar, Pelin; Gök, Müslüm; Bodur, Ebru (SPRINGER/PLENUM PUBLISHERS, 2021)Phenylketonuria (PKU) is an inborn error disease in phenylalanine metabolism resulting from defects in the stages of converting phenylalanine to tyrosine. Although the pathophysiology of PKU is not elucidated yet, the toxic ... -
Comparison of the catalytic activity of butyrylcholinesterase and lipases using 4-mu palmitate as substrate
Gök, Müslüm; Çiçek, C.; Sarı, S.; Bodur, E. (WILEY, 2022)Comparison of the catalytic activity of butyrylcholinesterase ... -
Indole Metabolites as Modulators of Human Cholinesterases: A Kinetic and Molecular Docking Study with Comparison to Alzheimer's Drugs
Gök, Müslüm; Çiçek, Çiğdem; Sarı, Suat; Sönmez, Gamze; Bodur, Ebru (Pera Yayincilik Hizmetleri, 2026)Objective: Alzheimer's disease (AD) is characterised by the gradual decline of cognitive function and impaired cholinergic neurotransmission due to reduced brain acetylcholine levels. AChE and BChE regulate acetylcholine ... -
Melatonin is effective in attenuating cisplatin-induced neurotoxicity
Bayraktar, U. Arda; Arihan, Okan; Atalay, Özbeyen; Gök, Müslüm; Çiçek, Çiğdem; Bodur, Ebru; Tuncer, Meltem (WILEY, 2022)Cisplatin (Cis) is a chemotherapeutic agent that has many side effects. Neurotoxicity is one of the most important of these side effects. Oxidative stress and neuroinflammation are the best-known mechanisms in the pathogenesis ... -
Novel activity of human BChE: Lipid hydrolysis
Gök, Müslüm; Çiçek, Çiğdem; Sarı, Suat; Bodur, Ebru (ELSEVIER FRANCE, 2023)Acetylcholinesterase and butyrylcholinesterase (BChE) typically hydrolyze the neurotransmitter acetylcholine. The multifunctional enzyme BChE is associated with lipid metabolism through an undefined mechanism. Based on ...
