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1,25-dihydroxyvitamin D3 regulates t helper and b lymphocyte responses substantially in drug-naive primary Sjogren's syndrome patients' mononuclear cells
Genç, Deniz; Sezer Kürkçü, Merve; Günaydın, Burcu; Tarhan, Emine Figen (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2021)Background/aim: A correlation between vitamin D deficiency and primary Sjogren's syndrome (pSS) has already been described. The limited data has been reported regarding the pathological relevance of vitamin D in primary ... -
Comparison of innate lymphoid cells from tissue and blood in chronic tonsillitis and tonsillar hypertrophy
Çakıcı, Kerimcan; Gökdoğan, Ozan; Genç, Deniz; Günaydın, Burcu; Üçüncü, Harun (Elsevier Ireland Ltd, 2023)Object: Recurrent tonsillitis and tonsillar hypertrophy are two common diseases in children for which tonsillectomy is the definitive solution. The underlying causes of both diseases are not fully known. The aim of this ... -
Dental follicle mesenchymal stem cells ameliorated glandular dysfunction in Sjögren's syndrome murine model
Genç, Deniz; Bulut, Osman; Günaydın, Burcu; Göksu, Mizgin; Düzgün, Mert; Dere, Yelda; Sezgin, Serhat; Aladağ, Akın; Bülbül, Aziz (Plos, 2022)Objective: Dental mesenchymal stem cells (MSCs) are potential for use in tissue regeneration in inflammatory diseases due to their rapid proliferating, multilineage differentiation, and strong anti-inflammatory features. ... -
Immunoregulatory effects of dental mesenchymal stem cells on T and B lymphocyte responses in primary Sjogren's syndrome
Genç, Deniz; Günaydın, Burcu; Sezgin, Serhat; Aladağ, Akın; Tarhan, Emine Figen (FUTURE MEDICINE LTD, 2022)Background: In this article, the authors investigate the modulatory effects of dental mesenchymal stem cells (MSCs) on lymphocyte responses in primary Sjogren's syndrome (pSS), which is an autoimmune disease resulting from ... -
Synovial fluid niche promoted differentiation of dental follicle mesenchymal stem cells toward chondrogenesis in rheumatoid arthritis
Genç, Deniz; Sezer Kürkçü, Merve; Yiğittürk, Gürkan; Günaydın, Burcu; Elbe, Hülya; Aladağ, Akın; Çöl, Bekir; Tarhan, Emine Figen (TURKISH LEAGUE AGAINST RHEUMATISM, 2022)Objectives: In this study, we aimed to investigate the differentiation potential of dental follicle mesenchymal stem cells (MSCs) in the synovial fluid (SF) niche of early-onset or end-stage rheumatoid arthritis (RA). ...