Yazar "Genç, Deniz" için listeleme
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1,25-dihydroxyvitamin D3 regulates t helper and b lymphocyte responses substantially in drug-naive primary Sjogren's syndrome patients' mononuclear cells
Genç, Deniz; Sezer Kürkçü, Merve; Günaydın, Burcu; Tarhan, Emine Figen (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2021)Background/aim: A correlation between vitamin D deficiency and primary Sjogren's syndrome (pSS) has already been described. The limited data has been reported regarding the pathological relevance of vitamin D in primary ... -
Apoptotic and Antiproliferative Effect of Gingiva Mesenchymal Stem Cells on Acute Leukemia T Cells
Genç, Deniz; Sezer Kürkçü, Merve; Sezgin, Serhat (GALENOS PUBL HOUSE, 2021)BACKGROUND/AIMS The aim of this study was to investigate the antiproliferative and apoptotic effect of gingiva-derived mesenchymal stem cells (GMSCs) on the Jurkal cells as I-cell acute lymphoblastic leukemia cell ... -
Asthma immunotherapy and treatment approaches with mesenchymal stem cells
Akkoc, Tunc; Genç, Deniz (Future Medicine Ltd, 2020)Asthma is a chronic inflammatory disease of the airways where exaggerated T helper 2 immune responses and inflammatory mediators play a role. Current asthma treatment options can effectively suppress symptoms and control ... -
Comparison of innate lymphoid cells from tissue and blood in chronic tonsillitis and tonsillar hypertrophy
Çakıcı, Kerimcan; Gökdoğan, Ozan; Genç, Deniz; Günaydın, Burcu; Üçüncü, Harun (Elsevier Ireland Ltd, 2023)Object: Recurrent tonsillitis and tonsillar hypertrophy are two common diseases in children for which tonsillectomy is the definitive solution. The underlying causes of both diseases are not fully known. The aim of this ... -
Cryopreservation of Deciduous Teeth Originated Mesenchymal Stem Cells with Different Techniques
Akkoç, Tolga; Genç, Deniz; Akkoç, Tunç (GALENOS PUBL HOUSE, 2023)Objective: Mesenchymal stem cells (MSCs) are not used immediately after isolation in experimental and clinical studies. Traditional freezing and thawing processes may affect the cell viability or immunological properties ... -
Dental follicle mesenchymal stem cells ameliorated glandular dysfunction in Sjögren's syndrome murine model
Genç, Deniz; Bulut, Osman; Günaydın, Burcu; Göksu, Mizgin; Düzgün, Mert; Dere, Yelda; Sezgin, Serhat; Aladağ, Akın; Bülbül, Aziz (Plos, 2022)Objective: Dental mesenchymal stem cells (MSCs) are potential for use in tissue regeneration in inflammatory diseases due to their rapid proliferating, multilineage differentiation, and strong anti-inflammatory features. ... -
Immunoregulatory effects of dental mesenchymal stem cells on T and B lymphocyte responses in primary Sjogren's syndrome
Genç, Deniz; Günaydın, Burcu; Sezgin, Serhat; Aladağ, Akın; Tarhan, Emine Figen (FUTURE MEDICINE LTD, 2022)Background: In this article, the authors investigate the modulatory effects of dental mesenchymal stem cells (MSCs) on lymphocyte responses in primary Sjogren's syndrome (pSS), which is an autoimmune disease resulting from ... -
Mesenchymal Stem Cells Combined With IFN gamma Induce Apoptosis of Breast Cancer Cells Partially Through TRAIL
Yenilmez, Ezgi Nurdan; Genç, Deniz; Farooqi, Ammad Ahmad; Tunoğlu, Servet; Zeybek, Ümit; Akkoç, Tunç; Yaylım, İlhan (Int Inst Anticancer Research, 2020)Background: Mesenchymal stem cells (MSCs) have gained remarkable attention because of their ability to dualistically regulate tumor growth. The main objective of this study was to evaluate the apoptotic effects of human ... -
Mesenchymal stem cells differentiate to retinal ganglion-like cells in rat glaucoma model induced by polystyrene microspheres
Eraslan, Muhsin; Çerman, Eren; Bozkurt, Süheyla; Genç, Deniz; Virlan, Aysın Tulunay (Elsevier Ltd, 2023)Aim: The study aimed to evaluate the differentiation ability of intravitreally injected rat bone marrow-derived mesenchymal stem cells (rBM-MSCs) to retinal ganglion-like cells in a polystyrene microsphere induced rat ... -
Synovial fluid niche promoted differentiation of dental follicle mesenchymal stem cells toward chondrogenesis in rheumatoid arthritis
Genç, Deniz; Sezer Kürkçü, Merve; Yiğittürk, Gürkan; Günaydın, Burcu; Elbe, Hülya; Aladağ, Akın; Çöl, Bekir; Tarhan, Emine Figen (TURKISH LEAGUE AGAINST RHEUMATISM, 2022)Objectives: In this study, we aimed to investigate the differentiation potential of dental follicle mesenchymal stem cells (MSCs) in the synovial fluid (SF) niche of early-onset or end-stage rheumatoid arthritis (RA). ... -
TNF-α, IL-1B and IL-6 affect the differentiation ability of dental pulp stem cells
Genç, Deniz; Sazak Öveçoğlu, Hesna; Akkoç, Tunç (PMC, 2023)Background: This in vitro study examined the effect of the inflammatory cytokines (tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6) on osteogenic, chondrogenic, and adipogenic differentiation of dental pulp ...
