Yazar "Sıcak, Yusuf" için listeleme
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Betanin and Nano-Calcium Carbonate Incorporated Polyvinyl alcohol/Starch Films for Active and Intelligent Packaging Applications
Kavas, Eslem; Terzioğlu, Pınar; Sıcak, Yusuf (Springer, 2023)Bio-based and biodegradable packaging are ideal for sustainable polymer packaging. In this study, cassava starch and polyvinyl alcohol (PVA) were used as the film-forming matrix, betanin (E-162) and nano-calcium carbonate ... -
Bioactivities and phenolic constituents relationship of Muğla thyme and pine honey of Turkey with the chemometric approach
Sıcak, Yusuf; Şahin Yağlıoğlu, Ayşe; Öztürk, Mehmet (Springer, 2021)The chemical ingredients of pine and thyme honey were studied, along with their medicinal activity properties. A method was validated for common honey compounds using LC-TOF/MS to analyze the ingredients. In vitro ... -
Chalcones bearing nitrogen-containing heterocyclics as multi-targeted inhibitors: Design, synthesis, biological evaluation and molecular docking studies
Sıcak, Yusuf; Kekeçmuhammed, Hüseyin; Karaküçük-İyidoğan, Ayşegül; Taşkın-Tok, Tuğba; Oruç-Emre, Emine Elçin; Öztürk, Mehmet (John Wiley and Sons Ltd, 2023)In this work, a series of chalcones (1a–d, 2a–d, 3a–d, 4a–d, and 5a–d) were designed and synthesized by Claisen–Schmidt condensation. Also, their chemical structures were elucidated using UV–Vis, FT IR, 1H NMR, 13C NMR, ... -
CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF ESSENTIAL OIL OF CITRUS SINENSIS: INTERACTION WITH AMPICILLIN AND FLUCONAZOLE
Erdoğan Eliuz, Elif Ayşe; Yabalak, Erdal; Sıcak, Yusuf (EDITURA ACAD ROMANE, 2020)In the present study, the interactions of essential oil (EO) of Citrus sinensis L. Osbeck with two antibiotics (ampicillin and fluconazole), which are commonly used in the treatment of infections, were investigated. C. ... -
Design and Antiproliferative and Antioxidant Activities of Furan-Based Thiosemicarbazides and 1,2,4-Triazoles: Their Structure-Activity Relationship and SwissADME Predictions
Sıcak, Yusuf (Springer, 2021)Due to the limited number of drugs in current clinical use, the diverse biological applications of furan have encouraged the preparation of a wide variety of thiosemicarbazide and triazole derivatives for the purpose of ... -
Design and Bioevaluation of Novel Hydrazide-Hydrazones Derived from 4-Acetyl-N-Substituted Benzenesulfonamide
Bozkurt, E; Sıcak, Yusuf; Oruç-Emre, E E; Iyidoğan, A Karaküçük; Öztürk, Mehmet (Maik Nauka/Interperiodica/Springer, 2020)In this research, a series of hydrazine-hydrazone derivatives (Ia-g), (IIa-h) were synthesized to discover new antioxidant and anticholinesterase agents. The structures of synthesized compounds were characterized by ... -
Design, in Silico Studies and Biological Evaluation of New Chiral Thiourea and 1,3-Thiazolidine-4,5-dione Derivatives
Evyapan, Samet; Oruç-Emre, Emine Elçin; Sıcak, Yusuf; Karaküçük-İyidoğan, Ayşegül; Öztürk, Mehmet; Yılmaz Tatar, Gizem (John Wiley and Sons Inc, 2023)In this study, new chiral thiourea and 1,3-thiazolidine-4,5-dione derivatives were synthesized, it was aimed to evaluate the various biological activities and molecular docking of these compounds. Firstly, the new thioureas ... -
Designing heterocyclic chalcones, benzoyl/sulfonyl hydrazones: An insight into their biological activities and molecular docking study
Aktar, Bedriye Seda Kursun; Sıcak, Yusuf; Tok, Tugba Taskin; Oruc-Emre, Emine Elcin; Yaglioglu, Ayse Sahin; Iyidogan, Aysegul Karakucuk; Demirtas, Ibrahim; Öztürk, Mehmet (Elsevier, 2020)The aim of this study is to investigate the antioxidant, anticholinesterase and the antiproliferative activities of some chalcones, benzoyl and sulfonyl hydrazones. The antioxidant activity was studied by way of four ... -
Effects of Hypericum perforatum extract on 6-hydroxydopamine neurotoxicity in differentiated SH-SY5Y cells
Bitmez, Barış; Gültekin, Seda; Albayrak, İrem; Deveci, Yiğit; Sıcak, Yusuf; Akalın, Emine (EGYPTIAN PHARMACEUTICAL JOURNAL, 2023)Background and objectiveParkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. In our study, PD model was created as a result of exposure to 6-hydroxydopamine (6-OHDA) in ... -
Microwave-assisted synthesis of new sulfonyl hydrazones, screening of biological activities and investigation of structure-activity relationship
Karaman, Nurcan; Oruç-Emre, Emine Elçin; Sıcak, Yusuf; Çatıkkaş, Berna; Karaküçük-İyidoğan, Ayşegül; Öztürk, Mehmet (Springer Birkhauser, 2016)Sulfonyl hydrazone scaffold and the piperidine rings have important role in medicinal chemistry. This study shows the synthesis of two novel series of sulfonyl hydrazone having piperidine derivatives by condensing benzene ... -
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors
Karaman, Nurcan; Sıcak, Yusuf; Taşkın-Tok, Tuğba; Öztürk, Mehmet; Karaküçük-İyidoğan, Ayşegül; Dikmen, Miris; Oruç-Emre, Emine Elçin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidi ... -
Novel fluorine-containing chiral hydrazide-hydrazones: Design, synthesis, structural elucidation, antioxidant and anticholinesterase activity, and in silico studies
Sıcak, Yusuf; Oruç-Emre, Emine Elçin; Öztürk, Mehmet; Taskın-Tok, Tuğba; Karaküçük-İyidoğan, Ayşegül (Wiley, 2019)In this study, a series of fluorine-containing chiral hydrazide-hydrazone derivatives [III-XII] from x29f; -cysteine ethyl ester hydrochloride was synthesized as new antioxidant and anticholinesterase agents. The antioxidant ... -
Pine honey-loaded electrospun poly (vinyl alcohol)/gelatin nanofibers with antioxidant properties
Parın, Fatma Nur; Terzioğu, Pınar; Sıcak, Yusuf; Yıldırım, Kenan; Öztürk, Mehmet (Taylor & Francis Ltd, 2020)In this study, bioactive fibers were produced using polyvinyl alcohol (PVA), gelatin and pine honey by using electrospinning method. The influence of honey content (0-15 wt%) on the infrared spectrum, morphology, average ... -
Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities
Kurşun Aktar, Bedriye Seda; Sıcak, Yusuf; Tatar, Gizem; Oruç Emre, Emine Elçin (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2021)Hydrazone compounds such as anticholinesterase, tyrosinase, and urease have high capacity in terms of antioxidant activity and enzyme inhibition activities. In this study, benzoyl hydrazones compounds (7a-7m) were synthesized ... -
Synthesis of novel chiral metal complexes derived from chiral thiosemicarbazide ligands as potential antioxidant agents
Basaran, Eyüp; Sıcak, Yusuf; Soğukömeroğulları, Hatice Gamze; Karaküçük-İyidoğan, Ayşegül; Oruç-Emre, Emine Elcin; Sönmez, Mehmet; Öztürk, Mehmet (Wiley, 2019)Two new chiral thiosemicarbazide ligands and their Cu (II), Ni (II), Pd (II), and Zn (II) complexes were synthesized and characterized by nuclear magnetic resonance (NMR) (only for ligand), Fourier transform infrared ... -
Synthesis, Antioxidant and Some Enzyme Inhibition Activities of New Sulfonyl Hydrazones and their Molecular Docking Simulations
Kurşun Aktar, Bedriye Seda; Sıcak, Yusuf; Tatar, Gizem; Oruç-Emre, Emine Elçin (Springer, 2022)In this work, a series of new sulfonyl hydrazones were synthesized and screened for antioxidant and anticholinesterase, tyrosinase and urease enzyme inhibition activities. In addition, molecular docking study was applied ... -
Synthesis, Characterization and Biological Evaluation of Novel Thiourea Derivatives
Tok, Fatih; Çakır, Cansel; Çam, Dilaycan; Kırpat, Mustafa Murat; Sıcak, Yusuf (Marmara Üniversitesi, 2022)Objective: A new series of 4-[3-(substitutedphenyl)thioureido]-N-(6-chloropyrazin-2-yl)benzenesulfonamide were synthesized from sulfaclozine. Methods: All compounds were characterized by IR, 1H-NMR spectroscopic methods ... -
Synthesis, characterization, and antioxidant and anticholinesterase activities of pyrazolo derivatives
Sıcak, Yusuf; Oruç Emre, Emine E.; Öztürk, Mehmet; Karakucuk İyidoğan, Ayşegül; Nadeem, Said (Wiley, 2020)Twenty-four pyrazolo derivatives (1-4)(a-f) were synthesized and characterized by FTIR, H-1, and C-13 NMR (Nuclear Magnetic Resonance), and elemental analysis. The synthesized compounds were also investigated for their ... -
Synthesis, predictions of drug-likeness, and pharmacokinetic properties of some chiral thioureas as potent enzyme inhibition agents
Sıcak, Yusuf (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2022)A series of chiral thioureas (1 - 17) were synthesized from and tested for their anticholinesterase, tyrosinase, and urease enzyme inhibitor activities. Various phenylisothiocyanates were added to solution of ??-cysteine ...
