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Chalcones bearing nitrogen-containing heterocyclics as multi-targeted inhibitors: Design, synthesis, biological evaluation and molecular docking studies
Sıcak, Yusuf; Kekeçmuhammed, Hüseyin; Karaküçük-İyidoğan, Ayşegül; Taşkın-Tok, Tuğba; Oruç-Emre, Emine Elçin; Öztürk, Mehmet (John Wiley and Sons Ltd, 2023)In this work, a series of chalcones (1a–d, 2a–d, 3a–d, 4a–d, and 5a–d) were designed and synthesized by Claisen–Schmidt condensation. Also, their chemical structures were elucidated using UV–Vis, FT IR, 1H NMR, 13C NMR, ... -
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors
Karaman, Nurcan; Sıcak, Yusuf; Taşkın-Tok, Tuğba; Öztürk, Mehmet; Karaküçük-İyidoğan, Ayşegül; Dikmen, Miris; Oruç-Emre, Emine Elçin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidi ...
