Yazar "Yiğittürk, Gürkan" için listeleme
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Anti-Inflammatory and Anti-Fibrotic Effects of Ursodeoxycholic Acid in Streptozocin-Induced Diabetic Rats
Canbolat, İsmail Polat; Yiğittürk, Gürkan; Erbaş, Oytun (Kocaeli Derince Eğitim ve Araştırma Hastanesi, 2020)INTRODUCTION: Diabetic cardiomyopathy is a consequence of free fatty acid oxidation, dysfunction in mitochondria, oxidative stress and diffuse myocardial fibrosis. We aimed to investigate the anti-inflammatory and anti-fibrotic ... -
Anticancer activity of linalool: comparative investigation of ultrastructural changes and apoptosis in breast cancer cells
Elbe, Hülya; Öztürk, Feral; Yiğittürk, Gürkan; Baygar, Tuba; Çavuşoğlu, Türker (TAYLOR & FRANCIS INC, 2022)Breast cancer is the most common cancer in women in the world. Many anticancer drugs are currently used clinically have been isolated from plant species or are based on such substances. Linalool is aromatic compounds from ... -
Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats
Abdulkareem Aljumaily, Sara Asaad; Demir, Mehmet; Elbe, Hülya; Yiğittürk, Gürkan; Biçer, Yasemin; Altınöz, Eyüp (Springer, 2021)Doxorubicin (DOX) is a well-known chemotherapeutic drug for most malignancies including breast cancer and leukemia whilst the usage of DOX is limited owing to its cardiotoxicity. In the present study, we aimed to investigate ... -
Cardio-protective effect of dapagliflozin against doxorubicin induced cardiomyopathy in rats
Belen, E.; Canpolat, I. P.; Yiğittürk, Gürkan; Çetinarslan, Ö. (VERDUCI PUBLISHER, 2022)OBJECTIVE: Cancer is the second most common non-communicable disease group in the world and its frequency is increasing. In parallel, side effects of drugs used in cancer treatment are frequently encountered. Doxorubicin ... -
Comparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Model
Kaya, Hüseyin; Sabah, Dündar; Keçeci, Burçin; Küçük, Levent; Erbaş, Oytun; Oltulu, Fatih; Taşkıran, Dilek (Taylor & Francis Inc, 2019)Aim of the study: Biologic reconstruction using tumor-bearing bone autografts devitalized by liquid nitrogen or extracorporeal irradiation (oncological sterilization) is a safe and effective method in musculoskeletal ... -
Comparison of ultrastructural changes and the anticarcinogenic effects of thymol and carvacrol on ovarian cancer cells: which is more effective?
Elbe, Hülya; Yiğittürk, Gürkan; Cavusoglu, Turker; Baygar, Tuba; Özgül Önal, Melike; Öztürk, Feral (Taylor & Francis Inc, 2020)Ovarian cancer is the seventh most common cancer worldwide in women. Many anticancer drugs are currently used clinically have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) ... -
Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology
Özkul, Bahattin; Sever, İbrahim Halil; Yiğittürk, Gürkan; Elgörmüş, Çağrı Serdar; Gür, Seray Gizem; Erbaş, Oytun (Turkish Association of Trauma and Emergency Surgery (TATES), 2023)Background: Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate ... -
Dexpanthenol reduces fibrosis and aids repair following nerve laceration and neurorrhaphy
Karahan, Gökhan; Kaya, Hüseyin; Eyceyurt, Recep Selçuk; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun (Spandidos Publications, 2021)The aim of the present study was to investigate the effect of dexpanthenol on nerve healing following neurorrhaphy in lacerated peripheral nerves. A total of 30 mature Sprague Dawley rats were used. Surgical sciatic nerve ... -
Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia
Erdoğan, Mümin Alper; Kirazlar, Mehmet; Yiğittürk, Gürkan; Erbaş, Oytun (Springer, 2022)Alzheimer's disease (AD) is by far the most common cause of cognitive impairment in older adults. Current treatments are entirely focused on the symptoms of AD. A complex etiology for AD has been proposed recently, in which ... -
Effects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarction
Demir, Mehmet; Altınöz, Eyüp; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Karayakalı, Melike (Taylor and Francis Ltd., 2021)The present study aimed to analyze the effects of pinealectomy and crocin treatment in isoproterenol-induced myocardial damage. Seventy rats were divided into seven groups: control, sham control, pinealectomy (PNX), ... -
THE EFFECTS OF RANOLAZINE ON COBALT CHLORIDE-INDUCED CHEMICAL HYPDXIA IN ENDOTHELIAL CELLS
Çekiç, Edip Güvenç; Yiğittürk, Gürkan; Önal, Melike; Elbe, Hülya; Başaran, Nesrin Filiz; Öztürk, Feral (POLSKIE TOWARZYSTWO FARMACEUTYCZNE, 2022)Ranolazine is beneficial when given as an adjunct to treatment in symptomatic angina pectoris. Therefore, it may be useful to evaluate the effect of ranolazine on cardiovascular endothelial cells in hypoxic conditions that ... -
The efficacy of Aesculus hippocastanum seeds on diabetic nephropathy in a streptozotocin-induced diabetic rat model
Elmas, Onur; Erbaş, Oytun; Yiğittürk, Gürkan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Cytokines, such as transforming growth factor (TGF)-beta 1, and increased oxidative stress are considered to be responsible for the development of diabetic nephropathy. We hypothesized that Aesculus hippocastanum (AH) seeds ... -
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taşkın, Banu; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Alper, Sibel; Erbaş, Oytun (Hindawi, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
Gürkan, Gökhan; Erdoğan, Mümin Alper; Karahan, Gökhan; Kaya, Hüseyin; Yiğittürk, Gürkan (Turkish Neurosurgical Society, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis
Haqi Ballur, Arwa Fadil; Altınöz, Eyüp; Yiğittürk, Gürkan; Özgül Önal, Melike; Elbe, Hülya (Springer, 2022)Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous ... -
The investigation of therapeutic potential of oxytocin and liraglutide on vincristine-induced neuropathy in rats
Erdogan, Mumin A.; Taskiran, Emin; Yiğittürk, Gürkan; Erbas, Oytun; Taskiran, Dilek (Wiley, 2020)The aim of this study was to assess the therapeutic potential of oxytocin and liraglutide (LIR), a GLP-1 analogue, in a rat model of vincristine-induced neuropathy. Rats were injected with vincristine (VCR) at a dose of 4 ... -
INVESTIGATION OF URSODEOXYCHOLIC ACID EFFECTS ON SIROLIMUS TREATED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS
Arısu Naghavi, Esra; Tekeli, Senem; Uynaıkgil, Yiğit; Göker Bağca, Bakiye; Yiğittürk, Gürkan; Gökçe, Burak; Tomruk, Canberk; Çavuşoğlu, Türker; Biray Avcı, Çığır; Gündüz, Cumhur (Süleyman Demirel Üniversitesi, 2022)Objective The usage of mesenchymal stem cells (MSC) with immunosuppressive drugs after organ transplantation is becoming remarkable in clinical applications. However, the drugs negatively affect MSCs. Ursodeoxycholic acid ... -
Is losartan a promising agent for the treatment of type 1 diabetes-induced testicular germ cell apoptosis in rats?
Buhur, Aylin; Gürel, Çevik; Kuşçu, Gökçe Ceren; Yiğittürk, Gürkan; Oltulu, Fatih; Karabay Yavaşoğlu, Nefise Ülkü; Uysal, Ayşegül; Yavaşoğlu, Altuğ (Springer Science and Business Media B.V., 2022)Background: Diabetes mellitus (DM) is common metabolic disease that poses a major risk to public health and fertility. Previous studies indicate that DM may cause male infertility by triggering oxidative stress and germ ... -
Leptin Accelerates Endothelial Wound Healing: Role of Endothelial Nitric Oxide Synthase Expression
Yiğittürk, Gürkan; Önal, Melike Özgül; Subaşı, Ekin; Doğan, Beyza; Türkmenoğlu, Melih; Kaplan, Merve; Yaşar, Volkan; Elbe, Hülya; Öztürk, Feral; 0000-0002-5315-253X (Turkish Society of Cardiology, 2022)Background: The endothelium is crucial for the control of vascular homeostasis and plays a role in angiogenesis. Leptin, a protein released mainly by adipose tissue, plays a key role in the regulation of energy balance and ... -
Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study
Hortu, Ismet; Ilgen, Orkun; Sahin, Cagdas; Akdemir, Ali; Yiğittürk, Gürkan; Erbas, Oytun (Taylor & Francis Inc, 2020)This study aimed to investigate the protective and antioxidant role of losartan in ovarian ischaemia and ischaemia/reperfusion injury in an experimental ovarian torsion model. Thirty adult female rats were used. Rats were ...
