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Lack of association between increased mitochondrial DNA(4977) deletion and ATP levels of sputum cells from chronic obstructive pulmonary disease patients versus healthy smokers
(Taylor & Francis Ltd, 2017)
In this study we looked at smokers with and without chronic obstructive pulmonary disease (COPD) patients in order to evaluate the incidence of 4977 base pair (bp) mtDNA (mtDNA(4977)) deletion and mtDNA copy number in ...
The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells
(Sage Publications Ltd, 2017)
Background: Silibinin is a bioactive flavonolignan extracted from milk thistle, known as Silybum marianum. Silibinin exerts strong antiproliferative, proapoptotic, and anti-inflammatory effects. Many studies have shown ...
IGF2BP2 gene polymorphism in patients with morbid obesity
(Allied Acad, 2017)
Background/Aim: In this study, it was aimed to determine the relationship between morbid obesity and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs1470579 and rs4402960 gene polymorphisms. Materials and ...
The IL-33 gene is related to increased susceptibility to systemic sclerosis
(Springer Heidelberg, 2016)
Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both ...
The relationship between attention deficit hyperactivity disorder and reelin gene polymorphicms in Turkish population
(Taylor & Francis Ltd, 2018)
PURPOSE: Although attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim of the present ...
MTUS1 tumor suppressor and its miRNA regulators in breast cancer
(Elsevier Science Bv, 2016)
Breast cancer is major public health problem predominantly effects female population. Current therapeutic approaches to deal with breast cancer are still lack of effectiveness. Thus, identifying/developing novel strategies ...
ENHO gene expression and serum adropin level in rheumatoid arthritis and systemic lupus erythematosus
(Wroclaw Medical Univ, 2018)
Background. Adropin, a secreted protein, is encoded by the energy homeostasis-associated gene (ENHO). It is expressed by a variety of tissues and cells. It has been implicated in several physiological and pathological ...
THE METHYLATION STATUS OF NKCC1 AND KCC2 IN THE PATIENTS WITH REFRACTORY TEMPORAL LOBE EPILEPSY
(Literatura Medica, 2019)
Purpose - Methylation is a key epigenetic modification of DNA and regarding its impact on epilepsy, it is argued that "DNA methylation may play an important role in seizure susceptibility and maintenance of the disorder". ...
Serum IL-33 level and IL-33 gene polymorphisms in Behcet's disease
(Springer Heidelberg, 2015)
Beh double dagger et's disease (BD) is a chronic inflammatory disease. Increased productions of cytokines including interleukin (IL)-1 beta and IL-18 are documented, and IL-1 alpha and beta gene polymorphisms are associated ...
The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms
(Taylor & Francis Ltd, 2018)
Our aim is to demonstrate any correlation between gestational diabetes mellitus (GDM) and polymorphism of the selenoprotein P (SEPP1) gene encoding the SEPP1 protein, having a role in the insulin resistance in GDM. Forty ...
