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dc.contributor.authorYıldırım, Betül Apaydın
dc.contributor.authorGedikli, Semin)
dc.contributor.authorKordalı, Şaban
dc.contributor.authorKüçükaydın, Selçuk
dc.date.accessioned2023-04-25T10:46:27Z
dc.date.available2023-04-25T10:46:27Z
dc.date.issued2023en_US
dc.identifier.citationBetul Apaydın Yildirim, Semin Gedikli, Saban Kordali & Selcuk Kucukaydin (2023) Apoptotic and antiproliferative effects of Inula viscosa L. water extract in the expression of microRnas on HCT 116 cell line: an in vitro study, International Journal of Environmental Health Research, DOI: 10.1080/09603123.2023.2197641en_US
dc.identifier.issn0960-3123 / 1369-1619
dc.identifier.urihttps://doi.org/10.1080/09603123.2023.2197641
dc.identifier.urihttps://hdl.handle.net/20.500.12809/10670
dc.description.abstractIn this study, the antiproliferative and apoptotic effects of Inula viscosa L. water extract (IVE) on HCT 116 has been examined, and the change in the expression of miRNAs. Phenolic compounds of IVE were determined as mu g/g extract using by HPLC-DAD. Quantitative determination of apoptosis, cell viability, IC50 values and miRNAs of the cells were determined during 24, and 48 hours. IVE contain coumarin, rosmarinic acid and chlorogenic acid. According to the findings of our study, the expression of miR-21 and miR-135a1 was upregulated, and miR-145 was downregulated in HCT 116 cells (Control). Additionally, IVE was found to have significant potential in regulating miRNAs, downregulating miR-21, miR-31 and miR-135a1, and upregulating miR-145 in HCT-116 cells. All these results show that the anticancer effect of IVE via regulating miRNAs' expression has been demonstrated for the first time, and may be candidate biomarkers in colorectal cancer.en_US
dc.item-language.isoengen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.isversionof10.1080/09603123.2023.2197641en_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioactive compoundsen_US
dc.subjectCellen_US
dc.subjectColorectal canceren_US
dc.titleApoptotic and antiproliferative effects of Inula viscosa L. water extract in the expression of microRnas on HCT 116 cell line: an in vitro studyen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fethiye Ziraat Fakültesi, Bitki Koruma Bölümüen_US
dc.contributor.authorID0000-0001-5669-5831en_US
dc.contributor.authorID0000-0001-8538-6528en_US
dc.contributor.institutionauthorKordalı, Şaban
dc.contributor.institutionauthorKüçükaydın, Selçuk
dc.relation.journalINTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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