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dc.contributor.authorGökçe Topkaya, Cansu
dc.contributor.authorSakallı Çetin, Esin
dc.contributor.authorGöktürk, Tolga
dc.contributor.authorKıncal, Sultan
dc.contributor.authorHökelek, Tuncer
dc.contributor.authorGüp, Ramazan
dc.date.accessioned2023-08-08T13:16:03Z
dc.date.available2023-08-08T13:16:03Z
dc.date.issued2023en_US
dc.identifier.citationTOPKAYA, C. G., ÇETİN, E. S., GÖKTÜRK, T., KINCAL, S., HÖKELEK, T., & Ramazan, G. Ü. P. (2023). Synthesis, Spectroscopic Characterization, Crystal Structure and Biological Properties of Novel Co-Crystal Copper (II) Complex Containing Dioxime Ligand. Inorganic Chemistry Communications, 111040.en_US
dc.identifier.issn13877003
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2023.111040
dc.identifier.urihttps://hdl.handle.net/20.500.12809/10867
dc.description.abstractThe title compound, co-crystal [(aqua) (1E,1′E,2E,2′E)-2,2′-(propane-1,3-diylbis(azaneylylidene)) bis(2-phenylacetaldehyde)dioximato] copper(II)chlorate, [Cu(HL1)ClO4]3, was synthesized from 1,3-diaminopropane and isonitrosoacetophenone. Its molecular and crystal structures were determined by single crystal X-ray analysis. The asymmetric unit of the newly synthesized co-crystal contains three crystallographically independent copper complex molecules and three uncoordinated chlorotetraoxide anions. The DNA binding activity of the Cu(II) complex was carried out by absorption spectra measurements and fluorescence spectroscopy. The results revealed that the binding mode of the complex with DNA is via minor groove. The concentration and time dependent DNA cleavage studies including cleavage mechanism of the complex were performed by employing gel electrophoresis assay, where the complex has been found to cleave supercoiled DNA with high efficiency. Topoisomerase I and IIα inhibition assays with Cu(II) complex were performed and complex showed strong inhibition against both enzymes. The cytotoxic activity of the complex was performed on human cell lines, lung carcinoma cell line (A549), colorectal adenocarcinoma cell line (HT29), hepatocellular carcinoma cell line (HepG2), breast cancer cell line (MDA-MB-231) and prostate cancer cell lines (LnCaP) by MTT assay. Annexin V, MMP and ROS assays were also performed. The complex was exhibited significant in vitro cytotoxicity against HepG2 and LnCaP.en_US
dc.item-language.isoengen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionof10.1016/j.inoche.2023.111040en_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCo-cyrstalen_US
dc.subjectCu(II) complexen_US
dc.subjectTopoisomerase inhibitionen_US
dc.subjectAnticancer activityen_US
dc.subjectCytotoxicityen_US
dc.titleSynthesis, spectroscopic characterization, crystal structure and biological properties of novel co-crystal copper(II) complex containing dioxime liganden_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Kimya Bölümüen_US
dc.contributor.authorID0000-0002-6834-4841en_US
dc.contributor.authorID0000-0002-7234-8079en_US
dc.contributor.authorID0000-0003-3865-9671en_US
dc.contributor.authorID0000-0001-5731-6733en_US
dc.contributor.institutionauthorGökçe Topkaya, Cansu
dc.contributor.institutionauthorSakallı Çetin, Esin
dc.contributor.institutionauthorGöktürk, Tolga
dc.contributor.institutionauthorKıncal, Sultan
dc.identifier.volume155en_US
dc.relation.journalInorganic Chemistry Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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