• Türkçe
    • English
  • Türkçe 
    • Türkçe
    • English
  • Giriş
Öğe Göster 
  •   DSpace@Muğla
  • Fakülteler
  • Fen Fakültesi
  • Kimya Bölümü Koleksiyonu
  • Öğe Göster
  •   DSpace@Muğla
  • Fakülteler
  • Fen Fakültesi
  • Kimya Bölümü Koleksiyonu
  • Öğe Göster
JavaScript is disabled for your browser. Some features of this site may not work without it.

Assessing the Acute Toxicological Effects of Annona muricata Leaf Ethanol Extract on Rats: Biochemical, Histopathological, and Metabolomics Analyses

Thumbnail

Göster/Aç

Tam metin / Article (4.523Mb)

Tarih

2023

Yazar

Zubaidi, Siti Norliyana
Qadi, Wasim S. M.
Maarof, Syahida
Hellal, Khaoula

Üst veri

Tüm öğe kaydını göster

Künye

Zubaidi, S.N.; Qadi, W.S.M.; Maarof, S.; Mohmad Misnan, N.; Mohammad Noor, H.S.; Hamezah, H.S.; Baharum, S.N.; Rosli, N.; Jam, F.A.; Al-Olayan, E.; et al. Assessing the Acute Toxicological Effects of Annona muricata Leaf Ethanol Extract on Rats: Biochemical, Histopathological, and Metabolomics Analyses. Toxics 2023, 11, 688. https://doi.org/10.3390/toxics11080688

Özet

Annona muricata is a common plant used in Africa and South America to manage various types of disease. However, there is insufficient toxicological information or published standard available regarding repeated dose animal toxicity data. As part of the safety assessment, we exposed Sprague Dawley rats to an acute oral toxicity of A. muricata. The intent of the current study was to use advanced proton nuclear magnetic resonance (H-1 NMR) in serum and urinary metabolomics evaluation techniques to provide the in vivo acute toxicological profile of A. muricata leaf ethanol extract in accordance with the Organization for Economic Co-operation and Development's (OECD) 423 guidelines. A single 2000 mg/kg dose of A. muricata leaf ethanol extract was administered to Sprague Dawley rats over an observational period of 14 days. The toxicity evaluation (physical and behavior observation, body weight, renal function test, liver function test and H-1 NMR analysis) showed no abnormal toxicity. Histopathological analysis manifested mild changes, i.e., the treated kidney manifested mild hypercellularity of mesangial cells and mild red blood cell congestion. In addition, there was mild hemorrhage into tissue with scattered inflammatory cells and mild dilated central vein with fibrosis in the liver. However, the changes were very mild and not significant which correlate with other analyses conducted in this study (biochemical test and H-1 NMR metabolomic analysis). On the other hand, urinary H-1 NMR analysis collected on day 15 revealed high similarity on the metabolite variations for both untreated and treated groups. Importantly, the outcomes suggest that A. muricata leaf ethanol extract can be safely consumed at a dose of 2000 mg/kg and the LD50 must be more than 2000 mg/kg.

Kaynak

TOXICS

Cilt

11

Sayı

8

Bağlantı

https://doi.org/10.3390/toxics11080688
https://hdl.handle.net/20.500.12809/10964

Koleksiyonlar

  • Kimya Bölümü Koleksiyonu [352]
  • WoS İndeksli Yayınlar Koleksiyonu [6466]



DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 




| Politika | Rehber | İletişim |

DSpace@Muğla

by OpenAIRE
Gelişmiş Arama

sherpa/romeo

Göz at

Tüm DSpaceBölümler & KoleksiyonlarTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreDile GöreBölüme GöreKategoriye GöreYayıncıya GöreErişim ŞekliKurum Yazarına GöreBu KoleksiyonTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreDile GöreBölüme GöreKategoriye GöreYayıncıya GöreErişim ŞekliKurum Yazarına Göre

Hesabım

GirişKayıt

DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 


|| Politika || Rehber|| Yönerge || Kütüphane || Muğla Sıtkı Koçman Üniversitesi || OAI-PMH ||

Muğla Sıtkı Koçman Üniversitesi, Muğla, Türkiye
İçerikte herhangi bir hata görürseniz, lütfen bildiriniz:

Creative Commons License
Muğla Sıtkı Koçman Üniversitesi Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Muğla:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.