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dc.contributor.authorEmren, Sadik Volkan
dc.contributor.authorZoghi, Mehdi
dc.contributor.authorBerilgen, Rida
dc.contributor.authorOzdemir, Ibrahim Halil
dc.contributor.authorÇelik, Oğuzhan
dc.contributor.authorCetin, Nurullah
dc.contributor.authorErgene, Oktay
dc.date.accessioned2020-11-20T14:51:06Z
dc.date.available2020-11-20T14:51:06Z
dc.date.issued2018
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.urihttps://doi.org/10.17305/bjbms.2017.2279
dc.identifier.urihttps://hdl.handle.net/20.500.12809/1684
dc.descriptionBASARAN, OZCAN/0000-0002-6384-6455; CETIN, NURULLAH/0000-0002-4158-5469; Zoghi, Mehdi/0000-0002-8156-2675en_US
dc.descriptionWOS: 000433285000010en_US
dc.descriptionPubMed ID: 28968197en_US
dc.description.abstractOnce-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) may increase patient adherence to treatment but may also be associated with a higher risk of bleeding. In this study, we investigated the adherence to once-or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September 2015 and 28 February 2016, included 2214 patients receiving NOACs for at least 3 months, due to NVAF. Patients receiving once-daily or twice-daily NOAC doses were 1: 1 propensity score matched for baseline demographic characteristics and the presence of other diseases. The medication adherence was assessed by the 8-item Morisky Medication Adherence Scale. Risk factors were investigated in relation to minor and major bleeding. The mean age of patients was 71 +/- 10 years, and 53% of the patients were women. The medication adherence was lower in patients receiving twice-daily NOAC doses compared to once-daily-dose group (47% versus 53%, p = 0.001), and there was no difference between the groups in terms of minor (15% versus 16%, p = 0.292) and major bleeding (3% versus 3%, p = 0.796). Independent risk factors for bleeding were non-adherence to medication (OR: 1.62, 95% CI: 1.23-2.14, p = 0.001), presence of 3 or more other diseases (OR: 10.3, 95% CI: 5.3-20.3, p < 0.001), and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR, Elderly, Drugs or alcohol) score (OR: 4.84, 95% CI: 4.04-5.8, p < 0.001). In summary, the once-daily dose of NOACs was associated with increased patient adherence to medication, while it was not associated with bleeding complications.en_US
dc.item-language.isoengen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDaily Dosingen_US
dc.subjectBleedingen_US
dc.subjectMedication Adherenceen_US
dc.subjectNon-Vitamin K Antagonist Oral Anticoagulantsen_US
dc.subjectSelf-Reporten_US
dc.subjectNoacsen_US
dc.subjectNonvalvular Atrial Fibrillationen_US
dc.subjectNVAFen_US
dc.titleSafety of once-or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: A NOAC-TR studyen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Emren, Sadik Volkan] Katip Celebi Univ, Dept Cardiol, Fac Med, Izmir, Turkey -- [Zoghi, Mehdi] Ege Univ, Dept Cardiol, Fac Med, Izmir, Turkey -- [Berilgen, Rida] Egepol Hosp, Dept Cardiol, Izmir, Turkey -- [Ozdemir, Ibrahim Halil] Celal Bayar Univ, Dept Cardiol, Manisa, Turkey -- [Celik, Oguzhan; Dogan, Tolga] Hitit Univ, Sch Med, Dept Cardiol, Corum, Turkey -- [Cetin, Nurullah] Karsiyaka State Hosp, Dept Cardiol, Izmir, Turkeyen_US
dc.identifier.doi10.17305/bjbms.2017.2279
dc.identifier.volume18en_US
dc.identifier.issue2en_US
dc.identifier.startpage185en_US
dc.identifier.endpage190en_US
dc.relation.journalBosnian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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