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dc.contributor.authorKara, Murat
dc.contributor.authorKirkil, Gamze
dc.contributor.authorKalemci, Serdar
dc.date.accessioned2020-11-20T15:03:41Z
dc.date.available2020-11-20T15:03:41Z
dc.date.issued2016
dc.identifier.issn1899-5276
dc.identifier.urihttps://doi.org/10.17219/acem/28343
dc.identifier.urihttps://hdl.handle.net/20.500.12809/2767
dc.descriptionWOS: 000372182800003en_US
dc.descriptionPubMed ID: 26935494en_US
dc.description.abstractBackground. This study aimed to investigate the associations of miRNA with COPD patients. Objectives. Chronic obstructive pulmonary disease (COPD) is characterized by progressive and largely irreversible airflow limitation. COPD is one of the most common causes of death globally and it is still a serious public health problem worldwide. Pathogenesis of COPD is multifactorial including genetics and environmental factors. Material and Methods. Sixty patients who were diagnosed with COPD according to GOLD guidance and 40 controls were involved in the study. This study was separated into four groups according to GOLD guidance. miR_16, miR_17, miR_29c, miR_92, miR_125, miR_126, miR_146, miR_155, miR_181, mir_122 expressions from the total miRNAs obtained were worked on by using real time-PCR method. The p-values are calculated based on a Student's t-test of the replicate 2(boolean AND) (-Delta Ct) values for each gene in the control group. Results. The miRNAs expressions in normal and COPD patients were found differentially. The miR-29c (p = 0.043) and -126 (p = 0.012) were found significantly different compared to control group. When their expressions are evaluated according to stage, miR-92 expression showed down regulation stage II and no change was observed in other miRNAs. miR-29c and miR-126 expressions showed significant differences in stage III and only miR-126 expression showed significant difference in stage IV. Conclusions. These results show that miRNA evaluations may give information about the diagnosis, staging and prognosis of the disease. In this study, we demonstrated that miR-29c and -126 are essential for the development of COPDen_US
dc.description.sponsorshipFIRAT University Scientific Research ProjectsFirat University [TF.12.73]en_US
dc.description.sponsorshipThis study was supported by grants from the FIRAT University Scientific Research Projects Unit (No. TF.12.73).en_US
dc.item-language.isoengen_US
dc.publisherWroclaw Medical Univen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOPDen_US
dc.subjectMicrornasen_US
dc.subjectSmoking Cigarettesen_US
dc.titleDifferential Expression of MicroRNAs in Chronic Obstructive Pulmonary Diseaseen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Kara, Murat] Mugla Sitki Kocman Univ, Dept Med Genet, Fac Med, Mugla, Turkey -- [Kirkil, Gamze] Firat Univ, Fac Med, Dept Chest Dis, Elazig, Turkey -- [Kalemci, Serdar] Mugla Sitki Kocman Univ, Dept Chest Dis, Fac Med, Elazig, Turkeyen_US
dc.identifier.doi10.17219/acem/28343
dc.identifier.volume25en_US
dc.identifier.issue1en_US
dc.identifier.startpage21en_US
dc.identifier.endpage26en_US
dc.relation.journalAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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