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dc.contributor.authorSahin, Cem
dc.contributor.authorKaynar, Leylagul
dc.contributor.authorKurnaz, Fatih
dc.contributor.authorPala, Gigdem
dc.contributor.authorSivgin, Serdar
dc.contributor.authorEser, Bulent
dc.contributor.authorUnal, Ali
dc.date.accessioned2020-11-20T16:21:24Z
dc.date.available2020-11-20T16:21:24Z
dc.date.issued2012
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.urihttps://doi.org/10.5152/etd.2012.48
dc.identifier.urihttps://hdl.handle.net/20.500.12809/4028
dc.descriptionKaynar, Leylagul/0000-0002-2035-9462en_US
dc.descriptionWOS: 000421225500006en_US
dc.description.abstractObjective: It was aimed to evaluate factors contributing to mortality in the post-transplantation period and determine the relative risk of death caused by these factors in patients who underwent allogeneic hematopoietic stem cell transplantation. Material and Methods: Outcomes of 184 patients who underwent stem cell transplantation were retrospectively assessed. The patients were classified by considering the factors such as diagnosis, health status at the time of transplantation, time of transplantation, time between diagnosis and transplantation, histocompatibility, donor-recipient gender compatibility, amount of CD34 stem cell which was given, preparation regimes and risk status at the time of diagnosis. Outcomes were analyzed statistically by Kaplan-Meier survival analysis, Cox regresion test and multivariate regresion test. Results: When confounding factors of transplant-related mortality were assessed using multivariate regression analysis, recurrent disease development was shown to be the most significant factor affecting mortality (hazard rate: 3.12; 95% CI: 2.02-4.82; p<.001). The other factors affecting mortality were chronic graft versus host disease (hazard rate: 1.92; 95% CI: 1.19-3.09; p=.008), high-risk status of patients with acute leukemia at diagnosis (hazard rate: 2.47; 95% CI: 1.47-4.14; p<.001) and acute graft versus host disease (hazard rate: 1.78; 95% CI: 1.10-2.88; p=.019). Conclusion: It is very important for each stem cell transplantation center to determine the risk groups for transplant-related mortality and morbidity and outcomes in their own patient groups.en_US
dc.item-language.isoturen_US
dc.publisherAvesen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematopoietic Stem Cell Transplantationen_US
dc.subjectAnalysisen_US
dc.subjectSurvivalen_US
dc.titleFactors That Affect Survival in Patients with Allogeneic Hematopoetic Stem Cell Transplantationen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Sahin, Cem; Kaynar, Leylagul; Kurnaz, Fatih; Pala, Gigdem] Mugla Univ Egitim Arastirma Hastanesi, Hastaliklari Anabilim Dali, Mugla, Turkey -- [Kaynar, Leylagul; Kurnaz, Fatih; Pala, Gigdem; Sivgin, Serdar; Eser, Bulent; Cetin, Mustafa; Unal, Ali] Erciyes Univ, Tip Fak Hematol Anabilim Dali, Kayseri, Turkey -- [Altuntas, Fevzi] Ankara Onkol Egitim Arastirma Hastanesi, Hematol Klin, Ankara, Turkeyen_US
dc.identifier.doi10.5152/etd.2012.48
dc.identifier.volume34en_US
dc.identifier.issue4en_US
dc.identifier.startpage178en_US
dc.identifier.endpage183en_US
dc.relation.journalErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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