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dc.contributor.authorŞengül, Elif Eda
dc.contributor.authorTopkaya, Cansu Gökçe
dc.contributor.authorGöktürk, Tolga
dc.contributor.authorGüp, Ramazan
dc.date.accessioned2020-11-20T14:39:26Z
dc.date.available2020-11-20T14:39:26Z
dc.date.issued2020
dc.identifier.issn1001-4861
dc.identifier.urihttps://doi.org/10.11862/CJIC.2020.149
dc.identifier.urihttps://hdl.handle.net/20.500.12809/431
dc.descriptionGokturk, Tolga/0000-0002-7234-8079en_US
dc.descriptionWOS: 000550789000015en_US
dc.description.abstractTwo new N, N, N-trimethylpropane-1-ammonium and N, N,N-trimethylpentane-1-ammonium conjugated acetophenone-(4-hydroxybenzohydrazone) ligands, (E)-3-(4-(1-(2-(4-hydroxybenzoyl)hydrazono)ethyl)phenoxy)-N,N, N-trimethylpropan-1-mmonium perchlorate (H2L1) and (E)-3-(4-(1-(2-(4-hydroxybenzoyl) hydrazono)ethyl)phenoxy). N, N,N-trimethylpentane-1-ammonium perchlorate (H2L2), and two new copper complexes with the formulation [Cu (HL1)(2)] and [Cu(HL2)(2)] were synthesized and their DNA binding and cleavage activities of the compounds were inves. tigated. The mechanism of DNA cleavage and the effect of the compound concentration on the DNA cleavage reac. tion were also studied. UV. Vis spectroscopy results suggest that all compounds preferably bind to DNA via major groove binding mode. This is also supported that DNA cleavage activity was inhibited in the presence of methyl green, a major groove binder. According to the results of electrophoresis studies, the compounds exhibit significant cleavage activity on the plasmid DNA both in the presence and absence of an oxidative agent (H2O2), which strongly depends on the concentration of the compound. The compounds cleavage pBR322 DNA via hydrolytic pathway, which is also supported by the DNA cleavage experiments in the presence of different radical scavengers.en_US
dc.description.sponsorshipMugla Sitki Kocman University Research Projects Coordination Office through ProjectMugla Sitki Kocman University [15/168]en_US
dc.description.sponsorshipSupported by the Mugla Sitki Kocman University Research Projects Coordination Office through Project (Grant No.15/168).en_US
dc.item-language.isoengen_US
dc.publisherChinese Chemical Socen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHydrazoneen_US
dc.subjectCopper(I) Complexen_US
dc.subjectCT-DNA Bindingen_US
dc.subjectPbr322 DNA Cleavageen_US
dc.titleSynthesis and Characterization of Copper(II) Complexes with Aroylhydrazone Ligands Containing Quaternary Ammonium Salts: in Vitro DNA Binding and Nuclease Activityen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Muğla Meslek Yüksekokulu, Kimya Ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Kimya Bölümü
dc.contributor.institutionauthorŞengül, Elif Eda
dc.contributor.institutionauthorTopkaya, Cansu Gökçe
dc.contributor.institutionauthorGöktürk, Tolga
dc.contributor.institutionauthorGüp, Ramazan
dc.identifier.doi10.11862/CJIC.2020.149
dc.identifier.volume36en_US
dc.identifier.issue7en_US
dc.identifier.startpage1333en_US
dc.identifier.endpage1343en_US
dc.relation.journalChinese Journal of Inorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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