Re: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12 mu g once daily via a Discair inhaler), tiotropium alone (18 mu g by Handihaler) or combined with formoterol (12 mu g twice daily by Aerolizer) in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019; 35(12):2187-2196
Özet
In the study, we saw that 12 patients in the TIOmono
group, 7 patients in the TIO/FORMbid group and 9 patients in
the TIO/FORMfixed group had had exacerbations in the last
year. In addition, the mean CAT score was 18.3 in the
TIOmono group, 17.1 in the TIO/FORMbid group and 17.1 in
the TIO/FORMfixed group. When compared with other groups,
we saw that patients in the TIOmono group had more exacerbations and were more symptomatic in the last year. In
patients with COPD, as the number of exacerbations and
symptoms increase, the severity of the disease increases and
response to inhaler therapy gets worse2
. We believe that this
condition may affect the results of the study.
