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dc.contributor.authorKüçükaydın, Selçuk
dc.contributor.authorÇayan, Fatih
dc.contributor.authorTel Çayan, Gülsen
dc.contributor.authorDuru, Mehmet Emin
dc.date.accessioned2021-09-09T06:39:47Z
dc.date.available2021-09-09T06:39:47Z
dc.date.issued2021en_US
dc.identifier.citationKüçükaydın S, Çayan F, Tel-Çayan G, Duru ME. HPLC-DAD phytochemical profiles of thymus cariensis and T. cilicicus with antioxidant, cytotoxic, anticholinesterase, anti-urease, anti-tyrosinase, and antidiabetic activities. S Afr J Bot [Internet]. 2021;143:155-63. Available from: www.scopus.comen_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2021.07.018
dc.identifier.urihttps://hdl.handle.net/20.500.12809/9521
dc.description.abstractThis study aimed to investigate the phytochemical compositions and biological activities of the Thymus cariensis and T. cilicicus. The phytochemical compositions were identified by HPLC-DAD. Luteolin, rosmarinic acid, and coumarin were the major compounds in the extracts of T. cariensis while rosmarinic and vanillic acids were the dominant compounds in the extracts of T. cilicicus. The methanol extract of T. cilicicus exhibited the highest antioxidant activity in β-carotene-linoleic acid (IC50: 9.65 ± 0.81 µg/mL), and CUPRAC (A0.50: 24.79 ± 0.02 µg/mL) assays while the methanol extract of T. cariensis were found to be active in DPPH• (IC50: 17.90 ± 0.15 µg/mL) and ABTS•+ (IC50: 12.71 ± 0.40 µg/mL) assays. The methanol extracts of T. cariensis and T. cilicicus showed the best cytotoxicity against MCF-7 with IC50 values of 27.65 ± 0.96, 83.57 ± 1.20 µg/mL, respectively. The methanol extract of T. cariensis was the most efficient extract against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), urease and tyrosinase enzymes whereas the hexane extract of T. cariensis was active against α-amylase and α-glucosidase enzymes. Moreover, a significant correlation was found between phenolic compounds and biological activities. These results show that Thymus species could be considered as a valuable resource for the food pharmaceutic and cosmetic industries due to their significant biological effects.en_US
dc.item-language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.sajb.2021.07.018en_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymus cariensisen_US
dc.subjectThymus cilicicusen_US
dc.subjectPhenolic compoundsen_US
dc.subjectBiological activityen_US
dc.subjectCytotoxicityen_US
dc.titleHPLC-DAD phytochemical profiles of Thymus cariensis and T. cilicicus with antioxidant, cytotoxic, anticholinesterase, anti-urease, anti-tyrosinase, and antidiabetic activitiesen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Köyceğiz Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler Ve Teknikler Bölümüen_US
dc.contributor.authorID0000-0001-8538-6528en_US
dc.contributor.institutionauthorKüçükaydın, Selçuk
dc.contributor.institutionauthorÇayan, Fatih
dc.contributor.institutionauthorTel Çayan, Gülsen
dc.contributor.institutionauthorDuru, Mehmet Emin
dc.identifier.volume143en_US
dc.identifier.startpage155en_US
dc.identifier.endpage163en_US
dc.relation.journalSouth African Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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