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dc.contributor.authorBeddiar, Hatem
dc.contributor.authorBoudiba, Sameh
dc.contributor.authorBenahmed, Merzoug
dc.contributor.authorCeylan, Özgür
dc.contributor.authorKüçükaydın, Selçuk
dc.date.accessioned2021-09-30T08:19:55Z
dc.date.available2021-09-30T08:19:55Z
dc.date.issued2021en_US
dc.identifier.citationBeddiar, H.; Boudiba, S.; Benahmed, M.; Tamfu, A.N.; Ceylan, Ö.; Hanini, K.; Kucukaydin, S.; Elomri, A.; Bensouici, C.; Laouer, H.; et al. Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of Clinopodium nepeta L. Kuntze. Plants 2021, 10, 1955. https://doi.org/10.3390/plants10091955en_US
dc.identifier.issn22237747
dc.identifier.urihttps://doi.org/10.3390/plants10091955
dc.identifier.urihttps://hdl.handle.net/20.500.12809/9557
dc.description.abstractPhenolic extracts of Clinopodium nepeta were prepared and their preliminary phenolic profiles determined using HPLC-DAD with 26 phenolic standards. Apigenin (21.75 ± 0.41 µg/g), myri-cetin (72.58 ± 0.57 µg/g), and rosmarinic acid (88.51 ± 0.55 µg/g) were the most abundant compounds in DCM (dichloromethane), AcOEt (ethyl acetate), and BuOH (butanol) extracts, respectively. The DCM and AcOEt extracts inhibited quorum-sensing mediated violacein production by C. violaceum CV12472. Anti-quorum-sensing zones on C. violaceum CV026 at MIC (minimal inhibitory concen-tration) were 10.3 ± 0.8 mm for DCM extract and 12.0 ± 0.5 mm for AcOEt extract. Extracts showed concentration-dependent inhibition of swarming motility on flagellated P. aeruginosa PA01 and at the highest test concentration of 100 µg/mL, AcOEt (35.42 ± 1.00%) extract displayed the best activ-ity. FRAP assay indicated that the BuOH extract (A0.50 = 17.42 ± 0.25 µg/mL) was more active than standard α-tocopherol (A0.50 = 34.93 ± 2.38 µg/mL). BuOH extract was more active than other extracts except in the ABTS●+, where the DCM extract was most active. This antioxidant activity could be attributed to the phenolic compounds detected. C. nepeta extracts showed moderate inhibition on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, and α-amylase. The results indicate that C. nepeta is a potent source of natural antioxidants that could be used in managing microbial resistance and Alzheimer′s disease.en_US
dc.item-language.isoengen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/plants10091955en_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC. nepetaen_US
dc.subjectPhenolic compoundsen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectAnti-quorum sensingen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectAlzheimer’s diseaseen_US
dc.titleChemical composition, anti-quorum sensing, enzyme inhibitory, and antioxidant properties of phenolic extracts of clinopodium nepeta l. Kuntzeen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Köyceğiz Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler Ve Teknikler Bölümüen_US
dc.contributor.authorID0000-0001-8538-6528en_US
dc.contributor.authorID0000-0002-1865-1093en_US
dc.contributor.institutionauthorCeylan, Özgür
dc.contributor.institutionauthorKüçükaydın, Selçuk
dc.identifier.volume10en_US
dc.identifier.issue9en_US
dc.relation.journalPlantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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