Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities
Citation
AKTAR, B. S. K., SICAK, Y., TATAR, G., & EMRE, E. E. (2022). Synthesis of benzoyl hydrazones having 4-hydroxy-3, 5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. TURKISH JOURNAL OF CHEMISTRY, 46(1), 236-252.Abstract
Hydrazone compounds such as anticholinesterase, tyrosinase, and urease have high capacity in terms of antioxidant activity and enzyme inhibition activities. In this study, benzoyl hydrazones compounds (7a-7m) were synthesized starting from 3,5-dimethoxy4-hydroxybenzaldehyde. Antioxidant activity of the synthesized compounds was evaluated. In the beta-carotene-linoleic acid and ABTS cation radical scavenging activities, compounds 7j, 7e, and 7m stand out as the most active compounds, respectively. In the anticholinesterase enzyme inhibition activity results, compound 7f exhibited the best activity against AChE and BChE enzymes in the synthesis series. In addition, molecular docking analysis was performed to understand the inhibition mechanism of the synthesized compounds with target enzymes at the atomic level. In the light of biological activity and in silico studies, it has the potential to guide clinical studies for the development of new drugs for Alzheimer disease in the future.
Source
TURKISH JOURNAL OF CHEMISTRYCollections
Related items
Showing items related by title, author, creator and subject.
-
Comparison of textile dyeing effluent adsorption on commercial activated carbon and activated carbon prepared from olive stone by ZnCl2 activation
Uğurlu, Mehmet; Gürses, Ahmet; Açıkyıldız, Metin (Elsevier, 2008)Adsorption of Remazol Red B on activated carbon prepared from olive stone and commercial activated carbon from aqueous solutions was compared. Different activating agent (ZnCl2) amounts and adsorbent particle size were ... -
ANTIBACTERIAL ACTIVITIES OF MELISSA OFFICINALIS L. EXTRACTS AGAINST VARIOUS MICROCOCCUS SPECIES ISOLATED FROM FOOTBALL PLAYER'S SHOES AND ITS ANTIOXIDANT ACTIVITIES
Ökmen, Ahmet Şadan (Jadoun Science Publishing Group, 2017)Objective / Purpose: The bacteria have an easier entry into the sportsman's epidermis. Particularly Staphylococcus aureus, commonly determined on the skin or in the nose. The purpose of the study is to search the lack of ... -
Antibacterial Activities of Mentha piperita L. Extracts Against Bacteria Isolated from Soccer Player's Shoes and its Antioxidant Activities
Okmen, Ahmet Sadan; Okmen, Gulten; Arslan, Ali; Vurkun, Mustafa (Assoc Pharmaceutical Teachers India, 2017)Objective: Microorganisms have an easier entry into the sportsman's epidermis, and these make diseases on athletes. The main scope of the study is to search the lack of information about the biological activities of Mentha ...