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dc.contributor.authorKurşun Aktar, Bedriye Seda
dc.contributor.authorSıcak, Yusuf
dc.contributor.authorTatar, Gizem
dc.contributor.authorOruç Emre, Emine Elçin
dc.date.accessioned2022-03-15T13:10:37Z
dc.date.available2022-03-15T13:10:37Z
dc.date.issued2021en_US
dc.identifier.citationAKTAR, B. S. K., SICAK, Y., TATAR, G., & EMRE, E. E. (2022). Synthesis of benzoyl hydrazones having 4-hydroxy-3, 5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. TURKISH JOURNAL OF CHEMISTRY, 46(1), 236-252.en_US
dc.identifier.issn1300-0527
dc.identifier.urihttps://hdl.handle.net/20.500.12809/9852
dc.description.abstractHydrazone compounds such as anticholinesterase, tyrosinase, and urease have high capacity in terms of antioxidant activity and enzyme inhibition activities. In this study, benzoyl hydrazones compounds (7a-7m) were synthesized starting from 3,5-dimethoxy4-hydroxybenzaldehyde. Antioxidant activity of the synthesized compounds was evaluated. In the beta-carotene-linoleic acid and ABTS cation radical scavenging activities, compounds 7j, 7e, and 7m stand out as the most active compounds, respectively. In the anticholinesterase enzyme inhibition activity results, compound 7f exhibited the best activity against AChE and BChE enzymes in the synthesis series. In addition, molecular docking analysis was performed to understand the inhibition mechanism of the synthesized compounds with target enzymes at the atomic level. In the light of biological activity and in silico studies, it has the potential to guide clinical studies for the development of new drugs for Alzheimer disease in the future.en_US
dc.item-language.isoengen_US
dc.publisherSCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAKen_US
dc.relation.isversionof10.3906/kim-2107-7en_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBenzoyl hydrazoneen_US
dc.subjectAntioxidant activityen_US
dc.subjectAnticholinesterase enzyme inhibitory activityen_US
dc.subjectTyrosinase enzyme inhibition activityen_US
dc.subjectUrease enzyme inhibition activityen_US
dc.subjectMolecular dockingen_US
dc.titleSynthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activitiesen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Köyceğiz Meslek Yüksekokulu, Bitkisel Ve Hayvansal Üretim Bölümüen_US
dc.contributor.institutionauthorSıcak, Yusuf
dc.relation.journalTURKISH JOURNAL OF CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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