dc.contributor.author | Kurşun Aktar, Bedriye Seda | |
dc.contributor.author | Sıcak, Yusuf | |
dc.contributor.author | Tatar, Gizem | |
dc.contributor.author | Oruç Emre, Emine Elçin | |
dc.date.accessioned | 2022-03-15T13:10:37Z | |
dc.date.available | 2022-03-15T13:10:37Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | AKTAR, B. S. K., SICAK, Y., TATAR, G., & EMRE, E. E. (2022). Synthesis of benzoyl hydrazones having 4-hydroxy-3, 5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities. TURKISH JOURNAL OF CHEMISTRY, 46(1), 236-252. | en_US |
dc.identifier.issn | 1300-0527 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12809/9852 | |
dc.description.abstract | Hydrazone compounds such as anticholinesterase, tyrosinase, and urease have high capacity in terms of antioxidant activity and enzyme inhibition activities. In this study, benzoyl hydrazones compounds (7a-7m) were synthesized starting from 3,5-dimethoxy4-hydroxybenzaldehyde. Antioxidant activity of the synthesized compounds was evaluated. In the beta-carotene-linoleic acid and ABTS cation radical scavenging activities, compounds 7j, 7e, and 7m stand out as the most active compounds, respectively. In the anticholinesterase enzyme inhibition activity results, compound 7f exhibited the best activity against AChE and BChE enzymes in the synthesis series. In addition, molecular docking analysis was performed to understand the inhibition mechanism of the synthesized compounds with target enzymes at the atomic level. In the light of biological activity and in silico studies, it has the potential to guide clinical studies for the development of new drugs for Alzheimer disease in the future. | en_US |
dc.item-language.iso | eng | en_US |
dc.publisher | SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK | en_US |
dc.relation.isversionof | 10.3906/kim-2107-7 | en_US |
dc.item-rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Benzoyl hydrazone | en_US |
dc.subject | Antioxidant activity | en_US |
dc.subject | Anticholinesterase enzyme inhibitory activity | en_US |
dc.subject | Tyrosinase enzyme inhibition activity | en_US |
dc.subject | Urease enzyme inhibition activity | en_US |
dc.subject | Molecular docking | en_US |
dc.title | Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities | en_US |
dc.item-type | article | en_US |
dc.contributor.department | MÜ, Köyceğiz Meslek Yüksekokulu, Bitkisel Ve Hayvansal Üretim Bölümü | en_US |
dc.contributor.institutionauthor | Sıcak, Yusuf | |
dc.relation.journal | TURKISH JOURNAL OF CHEMISTRY | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |