Comparison of Central Corneal Thickness Measurements with Four Different New Devices and Ultrasound Pachymetry

Abstract

Objectives: To assess the central corneal thickness (CCT) with 5 different devices, evaluate the repeatability of the devices, and determine the possible relationship between thickness values and sex. Materials and methods: The study included 308 eyes of 154 patients (76 women, 78 men) between the ages of 18-30 who presented to the Ophthalmology Clinic of Muğla Sıtkı Koçman University Training and Research Hospital. Autorefractor (Topcon, Japan), ultrasound pachymetry (UP) (Ceniscan, USA), high-resolution Pentacam (Oculus, USA), anterior segment-optical coherence tomography (AS-OCT) (Optovue, USA), and Spectralis AS-OCT (Heidelberg, Germany) measurements were assessed. Results: The mean age of the study participants was 23.2±0.2 years and the mean CCT was 540±14.1 μm, with no statistically significant difference in CCT between sexes (p>0.05). Mean CCT values were 557.0±26.7 μm with the autorefractor, 543.6±32.9 μm with UP, 533.8±30.2 μm with the Oculus Pentacam, 519.8±30.1 μm with Optovue AS-OCT, and 547.5±31.6 μm with Heidelberg AS-OCT. Pairwise comparisons between devices showed that the Optovue AS-OCT gave significantly lower CCT measurements than the autorefractor and Heidelberg AS-OCT device (p=0.027 and p=0.033, respectively). The coefficient of repeatability for autorefractor, UP, high-resolution Pentacam, Optovue AS-OCT, and Heidelberg AS-OCT CCT measurements were 1.51%, 2.46%, 3.72%, 2.57%, and 3.34%, respectively. Conclusion: Measurements made with five different devices showed that CCT was comparable and clinically usable. However, it was determined that the Optovue AS-OCT showed lower CCT values compare to other devices. When compared in terms of repeatability, it was found to be lower in the Pentacam than other devices.