The effect of mobile application-based rehabilitation in patients with Parkinson?s disease: A systematic review and meta-analysis

Abstract

Objective: Mobile app-based telerehabilitation is practical and cost-effective in neurological rehabilitation. The present systematic review aimed to investigate the effectiveness of mobile application-based rehabilitation in patients with Parkinson's Disease.Methods: Literature was searched via databases of "Web of Science (WoS), PubMed, Cochrane, Scopus and ScienceDirect". Physiotherapy Evidence Database (PEDro) and Revised Cochrane risk-of-bias tool for randomized trials (RoB2) were used to evaluate the quality analysis and risk of bias evaluation. Both narrative and quantitative synthesis were carried out.Results: A total of 2175 articles were screened (WoS=41, PubMed=42, Cochrane=84, Scopus=114, ScienceDirect=1894). A total of 5 studies were included in the systematic review following the screening and eligibility procedures. Two studies were enrolled in meta-analysis regarding the data homogeneity. PEDro scores of the trials ranged from 4 to 7 (median:6), indicating good quality. All studies were in the "some concerns" category. The mobile application-based intervention yielded better results on quality of life and patient adherence in two studies. Application-based rehabilitation was not superior to standard treatment on MiniBESTest (ES:0.15, 95 % CI:-0.33 to 0.26) and UPDRS III (ES:0.86, 95 % CI:-0.94 to 2.46) scores.Conclusion: Mobile application-based rehabilitation is not superior to standard treatments in balance and disease severity. However, mobile technologies could be preferred to increase patient adherence and quality of life. The limited study and the low number of cases in the review may reduce the level of evidence for the results.