THE EFFECT OF THE SELECTIVE CYCLOOXYGENASE II INHIBITOR PARECOXIB ON RENAL MORPHOLOGY AND FUNCTION IN ACUTE UNILATERAL URETERAL OBSTRUCTION

Abstract

Objectives: This experimental study aimed to examine the efficacy of parecoxib in the treatment of kidney obstruction. The histopathological and seintigraphic effects of the selective cyclooxygenase 11 (cox-in inhibitor parecoxib on renal morphology and function were determined following surgically induced unilateral ureteral obstruction. Materials and methods: The study included 20 male Spragne-Dawley rats that were assigned to 2 groups of 10 each The rats underwent diethylenetriamine pentaacetic acid (DTPA) renal scintigraphy to calculate basal glomerular filtration rate (GFR) values at the beginning of the study. The left ureters in groups 1 and 2 were ligated distally. The rats in group 2 received parecoxib 5 mg-kg(-1)d(-1), for 21 d post surgery, whereas those in group.] received nothing. At the end of postoperative d 21 DTPA renal scintigraphy was repeated in all the rats before undergoing bilateral nephrectomy. All kidneys were evaluated histologically. Results: Histologically, there were no differences between the right kidneys in groups 1 and 2, whereas the occurrence of cortical congestion, glomerular congestion, interstitial inflamation + congestion, and interstitial fibrosis was significantly lower in the left kidneys in group 2 than in those in group I (cortical congestion: P = 0.005; glomerular congestion: P = 0.03; interstitial infomation + congestion: P = 0.01; interstitial fibrosis:,P = 0.005). Scintigraphically; left kidney and right kidney CFR values in group 2 were higher than those in group I; the difference was significant (left kidneys: P = 0.001; right kidneys: P = 0.009). Conclusion: Histopathologically and scintigraphically, kidney function was preserved at the highest level in group 2. Parecoxib treatment was effective in preserving renal function in the obstructed and non obstructed (contralateral) kidneys, and can be administered during the obstruction period until the time radical treatment of obstruction can be performed.