Chemical Composition, Antioxidant and Anticholinesterase Activities of the Essential Oil of Salvia chrysophylla Staph

Abstract

The essential oil from the aerial parts of Salvia chrysophylla Staph (Lamiaceae), endemic to Turkey, was investigated by using GC and GC-MS. Fifty-four of 55 components, represented 99.52% of the total oil, were identified. The major components of the essential oil were found to be alpha-terpinenyl acetate (36.31%), beta-caryophyllene (15.29%), linalool (8.12%) and beta-elemene (4.26%). The antioxidant activity of the oil was investigated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and beta-carotene/linoleic acid tests. Anticholinesterase activity was screened against acetylcholinesterase and butyrylcholinesterase which are the chief enzymes of Alzheimer's disease. The essential oil showed weak antioxidant activity. However, at 1 mg/mL concentration, the essential oil exhibited mild acetylcholinesterase (52.5+/-2.0%) and moderate butyrylcholinesterase (76.5+/-2.7%) inhibitory activity