The effect of lycopene application on the antioxidant activity in liver and kidney tissues of diabetic rats

Abstract

The scope of the present study was to determine the effect of lycopene on the activity of malondialdehyde (MDA), glutathione, Vitamin A, vitamin E and catalase in liver and kidney tissues of diabetic rats. Wistar albino male rats were randomly allocated into four groups: control, diabetic, diabetic+lycopene and lycopene group (n=7). Rats in the respective groups were treated with intraperitoneal streptozotocin (45 mg/kg) to induce diabetes. Rats in the group lycopene and diabetic+lycopene were given orally 1 ml lycopene every day for 1 month. Catalase levels in the liver tissues of lycopene group was significantly lower than other groups (P<0.05). A significant decrease was observed at Vitamin A levels in the kidney tissues of the groups diabetic, diabetic+lycopene and lycopene compared to the control group (P<0.05). Other non-significant differences between the groups except catalase levels in liver tissue and Vitamin A levels in kidney tissues may be result of a short period of diabetes mellitus. The results of the present study supported the positive correlation among metabolic control and oxidative stress in diabetes mellitus. © 2019 Ataturk Universitesi. All rights reserved.