Boronic acid-functionalized silica microparticles for isolation of flavonoids from Hypericum perforatum

Abstract

We have selectively separated cis-and/or vicinal-diol-containing flavonoids from Hypericum perforatum (HP) by adsorption/desorption used aminophenylboronic acid (APBA) functionalized uniform (1.6 ?m) silica microparticles (BASPs) synthesized via the Stöber method. Silica particles were alkylated via its terminal –OH by 3-aminopropyl trimethoxysilane (APTS), glutaraldehyde (GA) and APBA. The results from model adsorption studies were indicated that these microparticles selectively had adsorbed quercetin and rutin but partially apigenin. The antioxidant and antiradical activities of the desorption solution were slightly higher than the post-adsorption solution. These results indicated that the BASP selectively adsorbed the cis-and/or vicinal antioxidant and antiradical flavonoids. © 2018, Turkish Chemical Society. All rights reserved.