Organotin (IV) complexes derived from Schiff base 1,3-bis[(1E)-1-(2-hydroxyphenyl)ethylidene] thiourea: synthesis, spectral investigation and biological study to molecular docking

Abstract

A novel Schiff base-derived organotin (IV) complexes have been synthesized by reacting 1, 3-bis [(1E)-1-(2-hydroxyphenyl) ethylidene]thiourea (which in turn obtained by condensing thiourea with ortho-hydroxyacetophenone) with diorganotin chlorides in methanol under stirring conditions. The synthesized compounds have been characterized by elemental analysis, FT-IR, NMR (1H, 13C, 119Sn), and Mass spectrometry. The results of the spectral study revealed that the ligand act as a tri-dentate in the complexes. Biological screenings demonstrate that the complexes possess significant activity against various bacterial and fungal strains while molecular docking has shown an intercalative mode of binding. The anti-angiogenic property was evaluated using CAM assay.