Yazar "Varol, Mehmet" için listeleme
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NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target
Aggarwal, Vaishali; Tuli, Hardeep Singh; Varol, Mehmet (Elsevier, 2021)Notch signaling, an evolutionarily conserved signaling cascade, is critical for normal biological processes of cell differentiation, development, and homeostasis. Deregulation of the Notch signaling pathway has been ... -
Organotin (IV) complexes derived from Schiff base 1,3-bis[(1E)-1-(2-hydroxyphenyl)ethylidene] thiourea: synthesis, spectral investigation and biological study to molecular docking
Abbas, Zahoor; Tuli, Hardeep Singh; Varol, Mehmet; Sharma, Shashi (Springer, 2021)A novel Schiff base-derived organotin (IV) complexes have been synthesized by reacting 1, 3-bis [(1E)-1-(2-hydroxyphenyl) ethylidene]thiourea (which in turn obtained by condensing thiourea with ortho-hydroxyacetophenone) ... -
Parietin as an efficient and promising anti-angiogenic and apoptotic small-molecule from Xanthoria parietina
Varol, Mehmet (Soc Brasileira Farmacognosia, 2019)Lichens that are exclusive symbiotic organisms composed of fungus and alga, are considered as a wealthy source of biologically and pharmacologically active small-molecules thanks to the tight metabolic relationship between ... -
Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance
Tuli, Hardeep Singh; Mittal, Sonam; Aggarwal, Diwakar; Parashar, Gaurav; Parashar, Nidarshana Chaturvedi; Upadhyay, Sushil Kumar; Sharma, Anil Kumar; Varol, Mehmet (Academic Press, 2020)In the last few decades, targeting cancer by the use of dietary phytochemicals has gained enormous attention. The plausible reason and believe or mind set behind this fact is attributed to either lesser or no side effects ... -
Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions
Tuli, Hardeep Singh; Rath, Prangya; Chauhan, Abhishek; Ramniwas, Seema; Vashishth, Kanupriya; Varol, Mehmet (MDPI, 2022)Phloretin is a natural dihydrochalcone found in many fruits and vegetables, especially in apple tree leaves and the Manchurian apricots, exhibiting several therapeutic properties, such as antioxidant, antidiabetic, ... -
Photodynamic therapy assay
Varol, Mehmet (Humana Press Inc., 2020)Photodynamic therapy is a promising, minimally invasive, and clinically approved treatment strategy that destroys the cell components by oxidizing the biological molecules such as nucleic acids, carbohydrates, proteins, ... -
Photoprotective activity assay toward ultraviolet B in human keratinocytes
Varol, Mehmet (Humana Press Inc., 2020)Design and discovery of novel sunscreens are of great importance to protect the human skin toward ultraviolet-induced damages because of the incidence of skin cancers that is believed to have increased depending on the ... -
Photoprotective Activity of Vulpinic and Gyrophoric Acids Toward Ultraviolet B-Induced Damage in Human Keratinocytes
Varol, Mehmet; Türk, Aysen; Candan, Mehmet; Tay, Turgay; Koparal, Ayşe Tansu (Wiley, 2016)Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations because of their chemical structures. However, to the best of our knowledge, there has been no reference to their cosmetic ... -
Photoprotective Properties of Natural Pulvinic Acid Derivatives toward Ultraviolet-Induced Damages
Varol, Mehmet (2018)Pulvinic acid derivatives are considered as worthy to be evaluated as skin protection factor toward ultraviolet-induced damages because of their colors and locations in lichens. Due to the lack of literature about ... -
Polymer-mediated nanoformulations: a promising strategy for cancer immunotherapy
Kaur, Simranjit; Saini, Adesh K.; Tuli, Hardeep Singh; Garg, Nancy; Joshi, Hemant; Varol, Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Engineering polymer-based nano-systems have attracted many researchers owing to their unique qualities like shape, size, porosity, mechanical strength, biocompatibility, and biodegradability. Both natural and synthetic ... -
Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements
Aggarwal, Vaishali; Tuli, Hardeep Singh; Varol, Ayşegül; Thakral, Falak; Yerer, Mükerrem Betül; Sak, Katrin; Sethi, Gautam; Varol, Mehmet (Mdpi, 2019)Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration ... -
STAT signaling as a target for intervention: from cancer inflammation and angiogenesis to non-coding RNAs modulation
Tuli, Hardeep Singh; Sak, Katrin; Iqubal, Ashif; Garg, Vivek Kumar; Varol, Mehmet; Sharma, Uttam (SPRINGER, 2022)As a landmark, scientific investigation in cytokine signaling and interferon-related anti-viral activity, signal transducer and activator of transcription (STAT) family of proteins was first discovered in the 1990s. Today, ... -
Synthesis, Structural Investigations, and In Vitro/In Silico Bioactivities of Flavonoid Substituted Biguanide: A Novel Schiff Base and Its Diorganotin (IV) Complexes
Abbas, Zahoor; Kumar, Manoj; Tuli, Hardeep Singh; M Janahi, Essam; Haque, Shafiul ; Harakeh, Steve; Varol, Mehmet (MDPI, 2022)Quercetin is one of the most powerful bioactive dietary flavonoids. The in vivo biological study of quercetin is extremely difficult due to its very low solubility. However, diorganotin complexes of quercetin are more ... -
Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential
Tuli, Hardep S; Aggarwal, Vaishali; Parashar, Gaurav; Aggarwal, Diwakar; Parashar, Nidarshana C; Tuorkey, Muobarak J; Varol, Mehmet; Sak, Katrin; Kumar, Manoj; Buttar, Harpal S. (Bentham Science Publishers, 2021)The overwhelming globalburden of cancer has posed numerous challenges and opportunities for developing anti-cancer therapies. Phytochemicalshave emerged as promising synergistic compounds with potential anti-cancer effects ...